<br>从Turbinaria decurrens中提取岩藻依聚糖及合成用于抗凝应用的岩藻依聚糖包覆的纳米银颗粒,ACS Omega

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从Turbinaria decurrens中提取岩藻依聚糖及合成用于抗凝应用的岩藻依聚糖包覆的纳米银颗粒
ACS Omega ( IF 3.7 ) Pub Date : 2021-11-09 , DOI: 10.1021/acsomega.1c03776
Nagarajan Shanthi ₁ , Ponnan Arumugam ₂ , Marudhamuthu Murugan ₃ , Muthiyal Prabakaran Sudhakar ₄ , Kulanthaiyesu Arunkumar ₅

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褐海藻通常含有藻酸盐作为主要聚合物。褐海藻中第二种主要的硫酸化聚合物是岩藻依聚糖，它在医学应用方面具有巨大的潜力。在本研究中，首先使用氯仿/甲醇以1:1（v/v）的比例提取Turbinaria decurrens的光合色素，然后提取岩藻依聚糖，产率分别为5.58%（粗品）和1.28%（纯化岩藻依聚糖）。海藻的干重，而海藻酸盐的提取率为海藻干重的 14.7%。分离的具有抗凝特性的岩藻依聚糖被鉴定并表征为 (1–3)-α -l-吡喃岩藻糖基残基，其硫酸基团主要位于 C ₄位，较小程度位于 C ₂位，而对于半乳糖，在C ₃和C ₆位置。使用分离的岩藻依聚糖合成的AgNPs具有很强的抗凝血活性，并且对革兰氏阴性临床细菌具有良好的抗菌性能。硫酸化岩藻依聚糖中与糖残基相关的 O-H、C-H 和 S=O 等官能团参与了纳米颗粒的合成，该纳米颗粒呈球形，尺寸范围为 10 至 60 nm，并表现出多分散性。从这项研究中，我们得出结论，从T. decurrens合成的岩藻依聚糖包被的阴离子 AgNP 在药物开发方面具有巨大的潜力。

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Extraction of Fucoidan from Turbinaria decurrens and the Synthesis of Fucoidan-Coated AgNPs for Anticoagulant Application

Brown seaweeds usually contain alginate as a major polymer. The second major sulfated polymer in brown seaweeds is fucoidan, which has huge potential in medicinal applications. In this study, the photosynthetic pigments from Turbinaria decurrens were first extracted using chloroform/methanol in the ratio of 1:1 (v/v), followed by fucoidan extraction with yields of 5.58% (crude) and 1.28% (purified fucoidan) from the dry weight of seaweed, whereas alginate was extracted with a yield of 14.7% DW of seaweed. The isolated fucoidan possessing anticoagulation property was identified and characterized as (1–3)-α-l-fucopyranosyl residues with sulfate groups primarily at the C₄ position and to a lesser extent at the C₂ position, whereas in the case of galactose, at the C₃ and C₆ positions. The AgNPs synthesized using isolated fucoidan exhibit strong anticoagulant activity and possess a good antibacterial property against Gram-negative clinical bacteria. Functional groups such as O–H, C–H, and S═O associated with sugar residues in sulfated fucoidan are involved in the synthesis of the nanoparticles with a spherical shape, size ranging from 10 to 60 nm, and showing polydispersity. From this study, we conclude that fucoidan-coated anionic AgNPs synthesized from T. decurrens have tremendous potential in drug development.

更新日期：2021-11-23

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