Anticorrosion and Cytocompatibility Assessment of Graphene-Doped Hybrid Silica and Plasma Electrolytic Oxidation Coatings for Biomedical Applications,ACS Biomaterials Science & Engineering

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Anticorrosion and Cytocompatibility Assessment of Graphene-Doped Hybrid Silica and Plasma Electrolytic Oxidation Coatings for Biomedical Applications
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2021-11-08 , DOI: 10.1021/acsbiomaterials.1c00326
Juan P Fernández-Hernán ₁ , Antonio J López ₁ , Belén Torres ₁ , Enrique Martínez-Campos ₂ , Endzhe Matykina ₃ , Joaquín Rams ₁

Affiliation

Magnesium AZ31 alloy substrates were coated with different coatings, including sol–gel silica-reinforced with graphene nanoplatelets, sol–gel silica, plasma electrolytic oxidation (PEO), and combinations of them, to improve cytocompatibility and control the corrosion rate. Electrochemical corrosion tests, as well as hydrogen evolution tests, were carried out using Hanks’ solution as the electrolyte to assess the anticorrosion behavior of the different coating systems in a simulated body fluid. Preliminary cytocompatibility assessment of the different coating systems was carried out by measuring the metabolic activity, deoxyribonucleic acid quantification, and the cell growth of premyoblastic C2C12-GFP cell cultures on the surface of the different coating systems. Anticorrosion behavior and cytocompatibility were improved with the application of the different coating systems. The use of combined PEO + SG and PEO + SG/GNP coatings significantly decreased the degradation of the specimens. The monolayer sol–gel coatings, with and without GNPs, presented the best cytocompatibility improvement.

中文翻译：

用于生物医学应用的石墨烯掺杂混合二氧化硅和等离子电解氧化涂层的防腐和细胞相容性评估

镁 AZ31 合金基材涂有不同的涂层，包括用石墨烯纳米片增强的溶胶-凝胶二氧化硅、溶胶-凝胶二氧化硅、等离子体电解氧化 (PEO) 以及它们的组合，以提高细胞相容性并控制腐蚀速率。使用汉克斯溶液作为电解质进行电化学腐蚀测试以及析氢测试，以评估模拟体液中不同涂层系统的防腐行为。通过测量代谢活性、脱氧核糖核酸定量和不同涂层系统表面上成肌细胞前 C2C12-GFP 细胞培养物的细胞生长，对不同涂层系统进行初步细胞相容性评估。随着不同涂层体系的应用，防腐性能和细胞相容性得到改善。使用组合的 PEO + SG 和 PEO + SG/GNP 涂层显着降低了试样的降解。具有和不具有 GNP 的单层溶胶-凝胶涂层表现出最佳的细胞相容性改善。

更新日期：2021-12-13

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