裂殖壶菌油及其与鱼油和印加果油的混合物通过脂肪酸合成酶/3-羟基-3-甲基戊二酰辅酶 A 还原酶/甾醇调节元件结合蛋白信号通路改善肠道微生物群组成和脂质代谢,European Journal of Lipid Science and Technology

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裂殖壶菌油及其与鱼油和印加果油的混合物通过脂肪酸合成酶/3-羟基-3-甲基戊二酰辅酶 A 还原酶/甾醇调节元件结合蛋白信号通路改善肠道微生物群组成和脂质代谢
European Journal of Lipid Science and Technology ( IF 1.8 ) Pub Date : 2021-11-06 , DOI: 10.1002/ejlt.202100108
Jie Chen ₁ , Yilin Liu ₁ , Ying Huang ₁ , Aijun Tong ₁ , Bin Liu _{1,

2} , Feng Zeng _{1,

2}

Affiliation

鱼油虽然富含多不饱和脂肪酸，但受环境污染物的影响很大。裂殖壶菌油和印加果油富含多不饱和脂肪酸，但对其降脂作用的研究较少。裂殖壶菌属油、鱼油和印加果油配制成 1:1:1 混合乳液 (SFSO)。实验结果表明，SFSO可显着降低血脂和肝脏总胆固醇（TC，30-40%）、甘油三酯（TG，35%）、低密度脂蛋白胆固醇（LDL-C，78.38%），增强抗氧化能力。此外，SFSO 显着降低 A-胆固醇酰基转移酶 (ACAT,86.5%)、脂肪酸合成酶 (FAS,96.16%)、3-羟基-3-甲基戊二酰辅酶 A 还原酶 (HMGCR,68.3%)、甾醇调节元件结合蛋白-1c（SREBP-1c，75.1%）和过氧化物酶体增殖物激活受体γ（PPAR-γ，17.23%）对脂肪合成相关基因的表达有很强的抑制作用。相反，它显着促进酰基辅酶A氧化酶1（ACOX1，85.54%）的mRNA表达，激素敏感性脂肪酶（HSL，61.84%）和过氧化物酶体增殖物激活受体α（PPAR-α，12.43%）加速脂肪代谢和脂肪酸氧化。肠道菌群分析显示，LSFSO组与肥胖和炎症相关的部分病原菌明显减少，而增加的Alloprevotella和Parabacteroides与多不饱和脂肪酸呈正相关。

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Schizochytrium Oil and Its Mixture with Fish Oil and Sacha inchi Oil Ameliorate Gut Microbiota Composition and Lipid Metabolism via the Fatty Acid Synthetase/3-hydroxy-3-methyl Glutaryl Coenzyme A Reductase/Sterol Regulatory Element Binding Protein Signaling Pathway

Although fish oil is rich in polyunsaturated fatty acids, it is greatly affected by environmental pollutants. Schizochytrium oil and Sacha inchi oil are rich in polyunsaturated fatty acids, but there are few studies on their lipid-lowering effects. The Schizochytrium oil, fish oil, and Sacha inchi oil are formulated into a 1:1:1 mixture emulsion (SFSO). Experimental results show that SFSO could significantly decrease blood lipid and liver total cholesterol (TC,30–40%), triglyceride (TG,35%), low-density lipoprotein cholesterol (LDL-C,78.38%), and enhance antioxidant capacity. In addition, SFSO significantly reduces the mRNA expression levels of A-cholesterol acyltransferase (ACAT,86.5%), fatty acid synthetase (FAS,96.16%), 3-hydroxy-3-methyl glutaryl coenzyme A reductase (HMGCR,68.3%), sterol regulatory element binding protein-1c (SREBP-1c,75.1%), and peroxisomal proliferator-activated receptors gamma (PPAR-γ,17.23%), has a strong inhibitory effect on the expression of fat synthesis-related genes. On the contrary, it significantly promotes the mRNA expression of acyl-CoA oxidase-1 (ACOX1,85.54%), hormone-sensitive lipase (HSL,61.84%), and peroxisomal proliferator-activated receptors alpha (PPAR-α,12.43%), accelerates the metabolism of fat and the oxidation of fatty acids. The analysis of gut microbiota shows that some pathogenic bacteria associated with obesity and inflammation in LSFSO group decreased significantly, and the increased Alloprevotella and Parabacteroides are positively correlated with polyunsaturated fatty acids.

更新日期：2021-11-06

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