1,2,4-Triazoles are important heterocyclic motifs that are widely found in molecular architectures with medicinal and pharmaceutical properties. Considering the importance of these scaffolds, many works have been published over the last few decades. This review provides a focus on the synthetic approaches towards 1,2,4-triazole derivatives from common precursors such as amidines, imidates, amidrazones, aryldiazoniums and hydrazones over the last decade. This review also aims to provide an overview of triazole derivatives biological properties within the last two years.

中文翻译：

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1,2,4-三唑化学的最新进展：合成、反应性和生物活性

1,2,4-三唑是重要的杂环基序，广泛存在于具有药用和药物特性的分子结构中。考虑到这些支架的重要性，在过去的几十年里已经发表了许多作品。本综述重点介绍了过去十年中从常见前体（如脒、亚胺酯、脒腙、芳基重氮和腙）合成 1,2,4-三唑衍生物的方法。本综述还旨在概述过去两年内三唑衍生物的生物学特性。