Solvents are crucial platforms in organic synthesis. Thereby, the choice of a solvent is critical in order to develop sustainable eco-friendly synthetic methodologies. Hence, the present consensus is to employ environmentally friendly solvents which have broad applications in fine chemical syntheses, especially from the context of large-scale industrial preparations. In this review, we provide several examples for the utilization of 2-MeTHF, CPME, and 4-MeTHP in several organic reactions pertaining to organometallic-, organo-, and biocatalysis and highlight their potential use as benign alternatives to conventional ether solvents. These solvents have favorable physical and chemical characteristics, such as low toxicity and high chemical and thermal stabilities, which make them promising media for a large breadth of synthetic chemistry and triggers development of reactions with green chemistry protocols.

中文翻译：

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有机化学中的非常规醚溶剂：2-甲基四氢呋喃、环戊基甲基醚和 4-甲基四氢吡喃的应用前景

溶剂是有机合成中的关键平台。因此，溶剂的选择对于开发可持续的环保合成方法至关重要。因此，目前的共识是使用在精细化学合成中具有广泛应用的环保溶剂，特别是在大规模工业制备的背景下。在这篇综述中，我们提供了几个例子来说明 2-MeTHF、CPME 和 4-MeTHP 在与有机金属催化、有机催化和生物催化有关的几种有机反应中的应用，并强调了它们作为传统醚溶剂的良性替代品的潜在用途。这些溶剂具有良好的物理和化学特性，如低毒、高化学和热稳定性，