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A novel reversible fluorescent probe based on naphthalimide for sequential detection of aluminum (Al3+) and fluoride (F−) ions and its applications
Analytical Methods ( IF 2.7 ) Pub Date : 2021-10-19 , DOI: 10.1039/d1ay01545a Shanzhu Zhang 1 , Yunlan Gu 2 , Zongqian Shi 1 , Nan Lu 1 , Haiyan Xu 1
Analytical Methods ( IF 2.7 ) Pub Date : 2021-10-19 , DOI: 10.1039/d1ay01545a Shanzhu Zhang 1 , Yunlan Gu 2 , Zongqian Shi 1 , Nan Lu 1 , Haiyan Xu 1
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A new Schiff base fluorescent probe NBP derived from the one-step condensation strategy of 2-butyl-6-hydroxy-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinoline-5-carbaldehyde and N-(2-(hydrazinecarbonyl)phenyl)benzamide was synthesized and characterized. NBP exhibited high selectivity toward Al3+ along with naked-eye color changes and prominent fluorescence enhancement. The limit of detection (LOD) of NBP toward Al3+ was detected to be 80 nM. The binding ratio of NBP with Al3+ ions was obtained as 1 : 2 on the basis of Job's plot with the association constant Ka value of 4.22 × 1010 M−1/2. The plausible complexation mechanism of NBP toward Al3+ ions was validated by the density functional theory (DFT) and IR spectrum. In addition, in situ formed “NBP + Al3+” could be utilized as the second sensor for selective recognition of F− via fluorescence quenching with a low detection limit (44 nM). Furthermore, the cell imaging experiments of probe NBP in HeLa cells have successfully demonstrated that NBP could serve as an indicator for monitoring Al3+ ions in living cells. On top of that, NBP could be used to prepare simple test paper strips for quickly and qualitatively detecting a trace amount of Al3+ ions in a visible manner.
中文翻译：
一种基于萘酰亚胺的新型可逆荧光探针用于连续检测铝（Al3+）和氟（F-）离子及其应用
2-丁基-6-羟基-1,3-二氧代-2,3-二氢-1 H-苯并[ de ]异喹啉-5-甲醛和N的一步缩合策略衍生出一种新的席夫碱荧光探针NBP合成并表征了-(2-(肼羰基)苯基)苯甲酰胺。NBP对Al 3+表现出高选择性，同时肉眼可见颜色变化和显着的荧光增强。NBP对Al 3+的检测限(LOD)被检测为80 nM。NBP与 Al 3+离子的结合比根据 Job's plot 与缔合常数K获得为 1:2值为4.22 × 10 10 M -1/2。通过密度泛函理论（DFT）和红外光谱验证了NBP对Al 3+离子的合理络合机制此外，原位形成的“ NBP + Al 3+ ”可用作第二传感器，通过荧光猝灭以低检测限（44 nM）选择性识别F - 。 此外，探针NBP在HeLa细胞中的细胞成像实验已经成功证明NBP可以作为监测活细胞中Al 3+离子的指标。最重要的是，NBP可用于制备简单的试纸条，以便以可见的方式快速、定性地检测痕量的 Al 3+离子。
更新日期：2021-11-03
中文翻译：
一种基于萘酰亚胺的新型可逆荧光探针用于连续检测铝（Al3+）和氟（F-）离子及其应用
2-丁基-6-羟基-1,3-二氧代-2,3-二氢-1 H-苯并[ de ]异喹啉-5-甲醛和N的一步缩合策略衍生出一种新的席夫碱荧光探针NBP合成并表征了-(2-(肼羰基)苯基)苯甲酰胺。NBP对Al 3+表现出高选择性，同时肉眼可见颜色变化和显着的荧光增强。NBP对Al 3+的检测限(LOD)被检测为80 nM。NBP与 Al 3+离子的结合比根据 Job's plot 与缔合常数K获得为 1:2值为4.22 × 10 10 M -1/2。通过密度泛函理论（DFT）和红外光谱验证了NBP对Al 3+离子的合理络合机制此外，原位形成的“ NBP + Al 3+ ”可用作第二传感器，通过荧光猝灭以低检测限（44 nM）选择性识别F - 。 此外，探针NBP在HeLa细胞中的细胞成像实验已经成功证明NBP可以作为监测活细胞中Al 3+离子的指标。最重要的是，NBP可用于制备简单的试纸条，以便以可见的方式快速、定性地检测痕量的 Al 3+离子。
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