Fluorination Triggers Fluoroalkylation: Nucleophilic Perfluoro-tert-butylation with 1,1-Dibromo-2,2-bis(trifluoromethyl)ethylene (DBBF) and CsF,Angewandte Chemie International Edition

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Fluorination Triggers Fluoroalkylation: Nucleophilic Perfluoro-tert-butylation with 1,1-Dibromo-2,2-bis(trifluoromethyl)ethylene (DBBF) and CsF
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2021-10-29 , DOI: 10.1002/anie.202113727
Qian Wang ₁ , Quan Tao _{2,

3,

4} , Hui Dong _{2,

3,

4} , Chuanfa Ni ₁ , Xiaoming Xie _{2,

3,

4} , Jinbo Hu ₁

Affiliation

A new perfluoro-tert-butylation protocol debuts: Consecutive triple fluorinations of 1,1-dibromo-2,2-bis(trifluoromethyl)ethylene (DBBF) generate (CF₃)₃C⁻ species, which enables efficient nucleophilic perfluoro-tert-butylation of various electrophiles. The C(CF₃)₃-containing products can be successfully applied in ¹⁹F-magnetic resonance imaging.

中文翻译：

氟化触发氟烷基化：使用 1,1-二溴-2,2-双（三氟甲基）乙烯 (DBBF) 和 CsF 进行亲核全氟叔丁基化

一种新的全氟叔丁基化方案首次亮相：1,1-二溴-2,2-双(三氟甲基)乙烯 (DBBF) 的连续三次氟化生成 (CF ₃ ) ₃ C ^-物质，可实现高效的亲核全氟叔丁基各种亲电子试剂的丁基化。该含C(CF ₃ ) ₃产物可成功应用于¹⁹ F-磁共振成像。

更新日期：2021-12-13

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