工程 DNA 纳米结构以操纵免疫受体信号传导和免疫细胞命运,Advanced Healthcare Materials

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工程 DNA 纳米结构以操纵免疫受体信号传导和免疫细胞命运
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2021-10-29 , DOI: 10.1002/adhm.202101844
Chung Yi Tseng ₁ , Wendy Xueyi Wang ₁ , Travis Robert Douglas ₁ , Leo Y T Chou ₁

Affiliation

免疫细胞感知、交流并在逻辑上整合大量环境信号，以做出重要的细胞命运决定并实现其效应器功能。这些过程由多种免疫受体启动和调节，并通过它们在配体结合时的动态时空组织。鉴于免疫系统与健康和疾病的广泛相关性，人们在理解控制免疫受体信号传导和激活的生物物理原理以及开发利用这些原理进行治疗性免疫工程的生物材料方面做出了重大努力。在这里，讨论了 DNA 纳米技术领域的进步如何构成一个不断增长的工具箱，以进一步追求这些努力。首先总结了参与诱导针对病原体或患病细胞的免疫的关键细胞参与者。然后介绍了如何利用设计具有自定义形状、动力学和特定位点结合不同客体的 DNA 纳米结构的能力来操纵调节这些过程的信号通路。随后重点介绍了 DNA 纳米技术在免疫工程十字路口的新兴应用，例如体外重组平台、疫苗和佐剂递送系统。最后，概述了进一步推进免疫调节 DNA 纳米器件的突出问题。并且可以利用特定地点的不同客人的结合来操纵调节这些过程的信号通路，然后呈现。随后重点介绍了 DNA 纳米技术在免疫工程十字路口的新兴应用，例如体外重组平台、疫苗和佐剂递送系统。最后，概述了进一步推进免疫调节 DNA 纳米器件的突出问题。并且可以利用特定地点的不同客人的结合来操纵调节这些过程的信号通路，然后呈现。随后重点介绍了 DNA 纳米技术在免疫工程十字路口的新兴应用，例如体外重组平台、疫苗和佐剂递送系统。最后，概述了进一步推进免疫调节 DNA 纳米器件的突出问题。

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Engineering DNA Nanostructures to Manipulate Immune Receptor Signaling and Immune Cell Fates

Immune cells sense, communicate, and logically integrate a multitude of environmental signals to make important cell-fate decisions and fulfill their effector functions. These processes are initiated and regulated by a diverse array of immune receptors and via their dynamic spatiotemporal organization upon ligand binding. Given the widespread relevance of the immune system to health and disease, there have been significant efforts toward understanding the biophysical principles governing immune receptor signaling and activation, as well as the development of biomaterials which exploit these principles for therapeutic immune engineering. Here, how advances in the field of DNA nanotechnology constitute a growing toolbox for further pursuit of these endeavors is discussed. Key cellular players involved in the induction of immunity against pathogens or diseased cells are first summarized. How the ability to design DNA nanostructures with custom shapes, dynamics, and with site-specific incorporation of diverse guests can be leveraged to manipulate the signaling pathways that regulate these processes is then presented. It is followed by highlighting emerging applications of DNA nanotechnology at the crossroads of immune engineering, such as in vitro reconstitution platforms, vaccines, and adjuvant delivery systems. Finally, outstanding questions that remain for further advancing immune-modulatory DNA nanodevices are outlined.

更新日期：2021-11-20

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