Calf diarrhoea has been a major cause of economic losses in the global dairy industry. Many factors, including multiple pathogen infections, can directly or indirectly cause calf diarrhoea. This study compared the faecal virome between 15 healthy calves and 15 calves with diarrhoea. Significantly lower diversity of viruses was found in samples from animals with diarrhoea than those in the healthy ones, and this feature may also be related to the age of the calves. Viruses belonging to the families Astroviridae and Caliciviridae that may cause diarrhoea in dairy calves have been characterized, which revealed that reads of caliciviruses and astroviruses in diarrhoea calves were much higher than those in healthy calves. Five complete genomic sequences closely related to Smacoviridae have been identified, which may participate in the regulation of the gut virus community ecology of healthy hosts together with bacteriophages. This research provides a theoretical basis for further understanding of known or potential enteric pathogens related to calf diarrhoea.

中文翻译：

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腹泻和健康奶牛肠道病毒群落的比较

犊牛腹泻已成为全球乳业经济损失的主要原因。许多因素，包括多种病原体感染，都可以直接或间接引起小牛腹泻。本研究比较了 15 头健康犊牛和 15 头腹泻犊牛的粪便病毒组。在腹泻动物样本中发现的病毒多样性明显低于健康动物样本，这一特征也可能与小牛的年龄有关。对可能导致奶牛腹泻的星状病毒科和杯状病毒科病毒进行了表征，这表明腹泻犊牛的杯状病毒和星状病毒的读数远高于健康犊牛的读数。五个完整的基因组序列已经鉴定出Smacoviridae，其可能与噬菌体一起参与健康宿主肠道病毒群落生态的调节。该研究为进一步了解与小牛腹泻相关的已知或潜在肠道病原体提供了理论基础。