Transparent and photochromic poly(hydroxyethyl acrylate–acrylamide)/WO3 hydrogel with antibacterial properties against bacterial keratitis in contact lens,Journal of Applied Polymer Science

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Transparent and photochromic poly(hydroxyethyl acrylate–acrylamide)/WO3 hydrogel with antibacterial properties against bacterial keratitis in contact lens
Journal of Applied Polymer Science ( IF 2.7 ) Pub Date : 2021-10-28 , DOI: 10.1002/app.51815
Onome Ejeromedoghene ₁ , Yi Ping Hu ₁ , Olayinka Oderinde ₂ , Fang Yao ₁ , Caroline Akinremi ₃ , Richard Akinyeye ₄ , Sheriff Adewuyi ₃ , Guodong Fu ₁

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There have been numerous challenges in the incorporation of photochromic materials into hydrogel system due to the agglomeration of nanoparticles and non-transparency of the hydrogel material. In this study, WO₃ nanocomposites were prepared and incorporated into poly(hydroxyethyl acrylate) (pHEA) and polyacrylamide (pAAm) to fabricate poly(HEA-AAm)/WO₃ hydrogels with improved coloration efficiency and reversibility. The as-prepared p(HEA-AAm)/WO₃ hydrogel displayed remarkable mechanical properties to sustain compressive and tensile stress up to 15.9 and 58.7 MPa with deformation ratios of 16.2 and 30.8, respectively. The hydrogels exhibited good transmittance (%T) and reflectance (%R) of ~47% and 64% at 829 and 408 nm respectively. The hydrogels also revealed visible spectroscopic absorbance at >781 nm after exposure to UV-lamp and natural sunlight for 5 s and 0.5 h, giving rise to a blue coloration, however, the fading process of the hydrogels was achieved in 20 min and 2.0 h respectively in an open air. More so, the hydrogel solutions displayed a high antibacterial efficacy against bacteria pathogens associated with bacterial keratitis in contact lens care solutions. The observed excellent photochromic and antibacterial properties of the hydrogel show promising potentials for use in the construction of antibacterial contact lenses, optical and intelligent devices.

中文翻译：

透明和光致变色聚（丙烯酸羟乙酯-丙烯酰胺）/WO3 水凝胶对隐形眼镜中的细菌性角膜炎具有抗菌性能

由于纳米颗粒的团聚和水凝胶材料的不透明性，在将光致变色材料加入水凝胶系统方面存在许多挑战。在本研究中，制备了WO ₃纳米复合材料并将其掺入聚（丙烯酸羟乙酯）（pHEA）和聚丙烯酰胺（pAAm）中，以制备具有改善的着色效率和可逆性的聚（HEA-AAm）/WO ₃水凝胶。制备的 p(HEA-AAm)/WO ₃水凝胶显示出卓越的机械性能，可承受高达 15.9 和 58.7 MPa 的压缩和拉伸应力，变形比分别为 16.2 和 30.8。水凝胶在 829 和 408 nm 处表现出良好的透射率 (%T) 和反射率 (%R)，分别为~47% 和 64%。在暴露于紫外线灯和自然阳光下 5 秒和 0.5 小时后，水凝胶还显示出大于 781 nm 的可见光谱吸收，产生蓝色，然而，水凝胶的褪色过程在 20 分钟和 2.0 小时内实现分别在露天。更重要的是，水凝胶溶液对隐形眼镜护理液中与细菌性角膜炎相关的细菌病原体显示出很高的抗菌功效。

更新日期：2022-01-02

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