A new one-pot synthesis of 3-(1,2,3,4-tetrahydroisoquinolin-1-yl)-isoquinolin-1(2H)-ones by DEAD-promoted oxidative Ugi–­Wittig reaction was developed. The sequential reactions of (2-carboxybenzyl)triphenylphosphonium salts, isocyanides, and N-aryl-1,2,3,4-tetrahydroisoquinolines produced 3-(1,2,3,4-tetrahydroisoquinolin-1-yl)-isoquinolin-1(2H)-ones in moderate to good overall yields in the presence of DEAD and Et3N.

中文翻译：

---

3-(1,2,3,4-Tetrahydroisoquinolin-1-yl)-isoquinolin-1(2H)-ones 以鏻盐前体为原料，通过 DEAD 促进的氧化 Ugi-Wittig 反应一锅法合成

开发了一种通过 DEAD 促进的氧化 Ugi-Wittig 反应一锅法合成 3-(1,2,3,4-四氢异喹啉-1-基)-异喹啉-1(2H)-酮的新方法。(2-羧基苄基)三苯基鏻盐、异氰化物和 N-芳基-1,2,3,4-四氢异喹啉的顺序反应产生 3-(1,2,3,4-四氢异喹啉-1-基)-异喹啉-1 (2H)-ones 在 DEAD 和 Et3N 存在下具有中等至良好的总产率。