Pyrimidine is a heterocyclic aromatic organic compound which is versatile lead compound for designing potent therapeutic agents. Different pyrimidine derivatives have been synthesized by various conventional methods and also from green methods. The pyrimidine moiety widely occurs in biologically occurring compounds, such as nucleic acids components, folic acid and vitamin B1 etc. This compound has various biological activities like anticancer, antitubercular, antimicrobial, antifungal, antibacterial, antioxidant, anticonvulsant, analgesic, CNS depressant, anti-inflammatory, anti-HIV, antihelmentic and herbicidal activity. Available data represents pyrimidine being heterocyclic six membered ring systems has various pharmacological actions and synthesis of pyrimidine and their derivatives are discussed.

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嘧啶及其药用综合研究

嘧啶是一种杂环芳族有机化合物，是设计有效治疗剂的通用先导化合物。不同的嘧啶衍生物已通过各种常规方法以及绿色方法合成。嘧啶部分广泛存在于生物化合物中，如核酸成分、叶酸和维生素 B 1等。该化合物具有多种生物活性，如抗癌、抗结核、抗菌、抗真菌、抗菌、抗氧化、抗惊厥、镇痛、中枢神经系统抑制剂、抗炎、抗 HIV、抗蠕虫和除草活性。现有数据表明嘧啶是杂环六元环系统，具有多种药理作用，并讨论了嘧啶及其衍生物的合成。