Zerumbone is a naturally occurring humulene type sesquiterpene, isolated from the rhizomes of Zingiber zerumbet (L.) Smith with excellent therapeutic potential and is recognized as a valuable synthon for the construction of diverse array of natural product motifs. In this review, we intended to highlight our achievements in utilizing abundant natural product zerumbone and its derivatives for the development of pharmacologically relevant molecular scaffolds. We provided an account of the transition-metal catalyzed 1,4-conjugate addition reactions of zerumbone and its derivatives along with palladium-catalyzed cross-couplings, transition metal-based Lewis acid promoted interrupted Nazarov cyclisation reaction with substituted indoles and transannular cyclizations, photo-induced transformations of zerumbone and its epoxide.

中文翻译：

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过渡金属/路易斯酸催化的 Zerumbone 反应用于不同的分子基序

Zerumbone 是一种天然存在的葎烯型倍半萜，从Zingiber zerumbet的根茎中分离出来(L.) Smith 具有出色的治疗潜力，被公认为构建多种天然产物基序的宝贵合成子。在这篇综述中，我们打算强调我们在利用丰富的天然产物泽龙骨及其衍生物开发药理学相关分子支架方面的成就。我们提供了过渡金属催化的 zerumbone 及其衍生物的 1,4-共轭加成反应以及钯催化的交叉偶联、基于过渡金属的路易斯酸促进了具有取代吲哚和跨环环化的中断 Nazarov 环化反应，照片-zerumbone 及其环氧化物的诱导转化。