Features of the reaction of 1-amino-2-nitroguanidine with isatins. Synthesis of [1,2,4]triazino[5,6-b]indoles,Chemistry of Heterocyclic Compounds

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Features of the reaction of 1-amino-2-nitroguanidine with isatins. Synthesis of [1,2,4]triazino[5,6-b]indoles
Chemistry of Heterocyclic Compounds ( IF 1.4 ) Pub Date : 2021-10-28 , DOI: 10.1007/s10593-021-03014-1
Tatiana P. Efimova ₁ , Mariya P. Ivanova ₁ , Tamara А. Novikova ₁ , Sergey V. Makarenko ₁

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Reactions of 1-amino-2-nitroguanidine with isatins leading to the formation of new β-(2-nitro)guanidinohydrazones of isatin, which exist as E/Z-isomers in regards to the azomethine fragment, were studied. It was found that the conditions of the reactions of 1-amino- 2-nitroguanidine with isatins affect the geometry of the formed hydrazones. Conditions for the cyclization of the obtained (Z)-β-(2-nitro)- guanidinohydrazones leading to 3-nitroimino-containing [1,2,4]triazino[5,6-b]indoles were proposed.

中文翻译：

1-氨基-2-硝基胍与靛红反应的特征。[1,2,4]三嗪基[5,6-b]吲哚的合成

研究了 1-氨基-2-硝基胍与靛红的反应，导致形成新的 β-（2-硝基）胍基腙，就偶氮甲碱片段而言，其作为E / Z异构体存在。发现1-氨基-2-硝基胍与靛红的反应条件影响所形成腙的几何形状。提出了所得( Z )-β-(2-硝基)-胍基腙环化生成含3-硝基亚氨基的[1,2,4]三嗪基[5,6- b ]吲哚的条件。

更新日期：2021-10-28

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