双胎妊娠全血细胞计数参考区间的建立,BMC Pregnancy and Childbirth

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双胎妊娠全血细胞计数参考区间的建立
BMC Pregnancy and Childbirth ( IF 2.8 ) Pub Date : 2021-10-26 , DOI: 10.1186/s12884-021-04192-8
Yifan Zeng _{1,

2,

3} , Lei Li _{1,

2} , Man Mao _{1,

2} , Xinghua Liang ₁ , Min Chen _{1,

2} , Yong Xia _{1,

2} , Wenyin He _{1,

2}

Affiliation

双胞胎妊娠的风险很高，近年来其发病率有所增加。为双胎妊娠妇女建立全血细胞计数 (CBC) 参考区间可能有助于不良结局的预后。分析了 1153 例双胎妊娠并发症的发生率和与不良结局相关的强度。在排除并发症和不良妊娠结局后，从所有候选人中筛选出双胞胎妊娠参考队列中的 253 例病例。采集妊娠中后期全血细胞计数资料，采用SPSS进行分析，建立双胎妊娠外周血参考区间。胎膜早破和盆腔炎与不良结局呈高度正相关，OR 值分别为 3.31 和 3.81。在结果正常的区间人群中，双胎妊娠妇女的红细胞 (RBC)、血红蛋白 (HGB)、血细胞比容 (HCT) 和血小板 (PLT) 值低于健康未孕妇女，但白细胞 (WBC)、中性粒细胞 (NEU) 和 NEU% 增加，尤其是在中期。使用 20 个双胎妊娠样本验证晚期妊娠的参考区间，然后用于确定早产 (PTB) 妊娠的独特 CBC 特征。根据我们建立的参考区间，PTB 妊娠中 WBC 和 NEU 的绝对值增加，这表明这些可能是这种不良结果的预后指标。

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Establishment of reference intervals of complete blood count for twin pregnancy

Twin pregnancy poses a high risk, and its incidence has increased in recent years. Establishment of reference intervals of complete blood count (CBC) for women with twin pregnancies during pregnancy may aid in the prognosis of adverse outcomes. The incidence of complications and the intensity associated with adverse outcomes were analyzed in 1153 cases of twin pregnancy. A total of 253 cases in the twin pregnancy reference cohort were screened from all candidates after complications and adverse pregnancy outcomes were excluded. Complete blood count data were collected during the mid- and late-term of pregnancy and analyzed using SPSS to establish the reference intervals for peripheral blood in twin pregnancy. Premature rupture of the membrane and pelvic inflammatory disease were highly positively correlated with adverse outcomes, with OR values of 3.31 and 3.81, respectively. Within the interval population with normal outcomes, red blood cell (RBC), hemoglobin (HGB), hematocrit (HCT), and platelet (PLT) values were lower in twin-pregnant women during gestation than in healthy nulligravida women, but the levels of white blood cells (WBC), neutrophils (NEU), and the NEU% increased, especially in the mid-term. The reference intervals of late-term pregnancy were validated using 20 twin pregnancies samples, and then utilized to determine the distinctive CBC characteristics in preterm birth (PTB) pregnancy. Absolute WBC and NEU values increased in PTB pregnancy based on our established reference intervals, which suggests that these may might be prognostic indicators of this adverse outcome. Establishing the reference interval of blood cell-related indicators of normal twin pregnancy is helpful for the monitoring and prognosis of gestation.

更新日期：2021-10-26

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