Selective Thiocyanation and Aromatic Amination To Achieve Organized Annulation of Enaminone with Thiocyanate,Organic Letters

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Selective Thiocyanation and Aromatic Amination To Achieve Organized Annulation of Enaminone with Thiocyanate
Organic Letters ( IF 4.9 ) Pub Date : 2021-10-25 , DOI: 10.1021/acs.orglett.1c03129
Jun Zhang ₁ , Mengyao She _{1,

2} , Lang Liu ₁ , Xukai Feng ₁ , Yao Li ₁ , Hua Liu ₁ , Tingting Zheng ₁ , Xin Leng ₁ , Ping Liu ₁ , Shengyong Zhang ₁ , Jianli Li ₁

Affiliation

A tandem insertion of thiocyanate to enamine was performed for the regioselective synthesis of multisubstituted benzoimidazo[2,1-b]thiazoles. This method was shown to be effective in addressing the issue of isomerization encountered in common strategies. With a change made to the leading group on the aniline fragment of enamine, the reaction achieved different transformations, thus enabling multisubstituted benzo[4,5]imidazo[2,1-b]thiazoles and thiazoles in satisfactory yields.

中文翻译：

选择性硫氰化和芳香胺化以实现烯胺酮与硫氰酸酯的有序环化

硫氰酸盐与烯胺的串联插入用于区域选择性合成多取代苯并咪唑并[2,1- b ]噻唑。该方法被证明可有效解决常见策略中遇到的异构化问题。通过改变烯胺苯胺片段上的前导基团，该反应实现了不同的转化，从而以令人满意的收率获得了多取代的苯并[4,5]咪唑并[2,1- b ]噻唑和噻唑。

更新日期：2021-11-05

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