天然存在的分子对通用和智能抗菌涂层的仿生整合,Advanced Functional Materials

当前位置： X-MOL 学术 › Adv. Funct. Mater. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

天然存在的分子对通用和智能抗菌涂层的仿生整合
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2021-10-23 , DOI: 10.1002/adfm.202108749
Lei Yang ₁ , Changping Wang ₂ , Lin Li ₃ , Fang Zhu ₁ , Xiancheng Ren ₁ , Quan Huang ₃ , Yiyun Cheng _{2,

4} , Yiwen Li ₁

Affiliation

具有按需抗生素释放曲线的表面独立智能抗菌涂层在医疗器械、抗生素输送平台和植入设备中引起了越来越多的关注。尽管有几种方法已得到充分证明，但在具有高抗生素负载效率、可调药物释放曲线和优异抗菌性能的通用基材上轻松制备抗菌涂层仍面临许多挑战，特别是与冗余涂层材料合成和选择性基材有关制造工艺。为了解决这个问题，作者报告了一种简单而稳健的制造方法，通过将两种天然存在的构建块一锅整合，在各种基材上实现智能抗菌涂层表面，植物酶辣根过氧化物酶存在下的氨基糖苷类和原儿茶醛。在一锅反应过程中，系统内同时动态亚胺键形成和酶促聚合使得能够轻松制造多种表面独立的智能抗菌涂层，这可以证明包括高载药量和动态（即pH响应）在内的几个有希望的特征特性、可调节和按需的抗生素释放行为以及体外和体内有效的抗菌活性。这项工作可能通过对所有天然构件的仿生整合，为坚固且通用的抗菌涂层材料提供新的机会。在一锅反应过程中，系统内同时动态亚胺键形成和酶促聚合使得能够轻松制造各种表面独立的智能抗菌涂层，这可以证明包括高载药量和动态（即pH响应）在内的几个有希望的特征特性、可调节和按需的抗生素释放行为以及体外和体内有效的抗菌活性。这项工作可能通过对所有天然构件的仿生整合，为坚固且通用的抗菌涂层材料提供新的机会。在一锅反应过程中，系统内同时动态亚胺键形成和酶促聚合使得能够轻松制造多种表面独立的智能抗菌涂层，这可以证明包括高载药量和动态（即pH响应）在内的几个有希望的特征特性、可调节和按需的抗生素释放行为以及体外和体内有效的抗菌活性。这项工作可能通过对所有天然构件的仿生整合，为坚固且通用的抗菌涂层材料提供新的机会。pH 响应）特性、可调节和按需的抗生素释放行为以及体外和体内有效的抗菌活性。这项工作可能通过对所有天然构件的仿生整合，为坚固且通用的抗菌涂层材料提供新的机会。pH 响应）特性、可调节和按需的抗生素释放行为以及体外和体内有效的抗菌活性。这项工作可能通过对所有天然构件的仿生整合，为坚固且通用的抗菌涂层材料提供新的机会。

"点击查看英文标题和摘要"

Bioinspired Integration of Naturally Occurring Molecules towards Universal and Smart Antibacterial Coatings

Surface-independent smart antibacterial coatings with on-demand antibiotics release profiles have attracted increasing attention in medical instruments, antibiotics delivery platforms, and implanted devices. Although several approaches have been well documented, the facile preparation of antibacterial coatings onto universal substrates with high antibiotics loading efficiencies, tunable drug release profiles, and excellent antibacterial performances is still met with many challenges, especially related to the redundant coating material synthesis and selective substrate fabrication process. To resolve this issue, the authors report a facile and robust fabrication method towards smart antibacterial coating surfaces on various substrates via a one-pot integration of two types of naturally occurring building blocks, aminoglycosides and protocatechualdehyde in the presence of plant enzyme horseradish peroxidase. The simultaneous dynamic imine bonds formation and enzymatic polymerization within the system during the one-pot reaction enable the facile fabrication of diverse surface-independent smart antibacterial coatings, which can demonstrate several promising features including high drug loading and dynamic (i.e., pH-responsive) properties, tunable and on-demand antibiotics release behaviors, and efficient antibacterial activities both in vitro and in vivo. This work may offer new opportunities towards the robust and universal antibacterial coating materials by the bioinspired integration of all natural building blocks.

更新日期：2021-10-23

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南

全部期刊列表>>