A Dual-Targeting Circular Aptamer Strategy Enables the Recognition of Different Leukemia Cells with Enhanced Binding Ability,Angewandte Chemie International Edition

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A Dual-Targeting Circular Aptamer Strategy Enables the Recognition of Different Leukemia Cells with Enhanced Binding Ability
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2021-10-22 , DOI: 10.1002/anie.202109500
Lili Ai ₁ , Tianhuan Peng ₁ , Yingying Li ₁ , Hailan Kuai ₁ , Yingyu Sima ₁ , Minhui Su ₁ , Dan Wang ₁ , Qiuxia Yang ₁ , Xue-Qiang Wang ₁ , Weihong Tan _{1,

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Affiliation

To enhance the recognition and internalization ability of aptamers, we designed a dual-targeting circular aptamer (DTCA) that can simultaneously recognize two different biomarkers on cancer cells to significantly improve aptamer–receptor interactions. This molecular engineering technique considerably boosts binding avidity and expands the recognition spectrum of these aptamers to different subtypes of leukemia cells.

中文翻译：

一种双靶向循环适体策略能够识别具有增强结合能力的不同白血病细胞

为了增强适体的识别和内化能力，我们设计了一种双靶向环状适体（DTCA），可以同时识别癌细胞上的两种不同生物标志物，以显着改善适体-受体相互作用。这种分子工程技术显着提高了结合亲和力，并将这些适体的识别范围扩大到不同亚型的白血病细胞。

更新日期：2021-10-22

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