ABSTRACT

Modelling the human cardiorespiratory system using computer simulation tools can serve to help physicians to comprehend the causes and development of cardiorespiratory diseases. The objective of this paper is to develop an integrated model of the cardiovascular and respiratory systems, along with their intrinsic control mechanisms, by combining analogous hydraulic-electric and diffusion-electric circuits, respectively. This modelling task is performed in object-oriented language in SIMSCAPE using the physical interconnected components to define the underlying dynamic equations. Simulation steady state results under rest and under variable physical exercise conditions, as well as under limiting conditions show a high qualitative agreement with clinical observations reported in literature. This object-oriented modelling approach, based on the combined use of electrical analogies, proves to be avaluable tool as a test bench for different strategies aimed to qualitative prediction of the effects of cardiorespiratory interactions during exercise, thus avoiding the formulation of complex mathematical models.

摘要

使用计算机模拟工具对人体心肺系统进行建模可以帮助医生理解心肺疾病的原因和发展。本文的目的是通过分别结合类似的液压电路和扩散电路，开发心血管和呼吸系统及其内在控制机制的集成模型。该建模任务在 SIMSCAPE 中以面向对象的语言执行，使用物理互连组件来定义底层动态方程。在休息和可变体育锻炼条件下以及在限制条件下的模拟稳态结果显示与文献中报告的临床观察结果高度一致。这种面向对象的建模方法，