A correlate of protection (CoP) is a measured adaptive immune response to vaccination or infection that is associated with protection against disease. However, the degree to which a CoP can serve as a surrogate end point for vaccine efficacy should depend on the robustness of this association. While cholera toxin is a dominant target of the human antibody response to Vibrio cholerae infection, antitoxin responses are not associated with long-term immunity, and are not effective CoPs for cholera. Instead, protection appears to be mediated by functional antibodies that target the O-polysaccharide coated V. cholerae outer membrane. Vibriocidal antibodies, which are complement-dependent bactericidal antibodies, remain the most accepted CoP for cholera and are used as surrogate end points in some vaccine studies. However, the association between vibriocidal antibody titers and immunity is not absolute, and they are unlikely to reflect a mechanistic correlate of protection against cholera.

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霍乱保护的相关性

保护相关性 (CoP) 是测量的对疫苗接种或感染的适应性免疫反应，与对疾病的保护有关。然而，CoP 可以作为疫苗效力的替代终点的程度应取决于这种关联的稳健性。虽然霍乱毒素是人类抗体对霍乱弧菌感染反应的主要目标，但抗毒素反应与长期免疫无关，也不是霍乱的有效 CoP。相反，保护似乎是由针对 O-多糖包被的霍乱弧菌外膜的功能性抗体介导的。杀弧菌抗体是补体依赖性杀菌抗体，仍然是最被接受的霍乱 CoP，并在一些疫苗研究中用作替代终点。然而，