Abstract

The homopolymer of 2-isopropyl-2-oxazoline (iPrOx) and iPrOx copolymers are extensively studied in recent years, and the interest on them is still growing. Poly(2-isopropyl-2-oxazoline) (PiPrOx), known as thermoresponsive pseudopeptide, exhibits a phase transition in aqueous solution at a temperature near human body temperature and is nontoxic to many cell lines. These facts make this polymer potentially attractive for many bioapplications. PiPrOx is similar in chemical structure to poly(N-isopropylacrylamide) (PNIPAM) and is considered as the alternative to this so-called “gold standard” thermoresponsive polymer, however significant differences in properties of these two polymers are worth attention. To control the properties, that directly translate into application possibilities, iPrOx was copolymerized with a wide range of different monomers, and, optionally, the obtained copolymers have been variously modified. This review summarizes the few-years-back research accomplishments and progress in studies on PiPrOx and iPrOx-based copolymers. Considering the recent developments, the properties of iPrOx-based (co)polymers are shown, aiming at promoting their great potential in the biomedical field. Having gathered the information on modification possibilities, structure-property relationship and applications, especially in the biomedical field, a bit of speculation on the future prospects of iPrOx-based (co)polymers is given.

摘要

2-异丙基-2-恶唑啉均聚物（iPrOx）和iPrOx共聚物近年来得到了广泛的研究，对它们的兴趣仍在不断增长。聚 (2-异丙基-2-恶唑啉) (PiPrOx)，称为热响应性假肽，在接近人体温度的温度下在水溶液中表现出相变，对许多细胞系无毒。这些事实使这种聚合物对许多生物应用具有潜在吸引力。PiPrOx 在化学结构上与 poly( N-异丙基丙烯酰胺）（PNIPAM）被认为是这种所谓的“金标准”热响应聚合物的替代品，但是这两种聚合物在性能上的显着差异值得关注。为了控制直接转化为应用可能性的性能，iPrOx 与各种不同的单体共聚，并且，任选地，得到的共聚物已经过各种改性。这篇综述总结了几年前关于 PiPrOx 和 iPrOx 基共聚物的研究成果和进展。考虑到最近的发展，展示了基于 iPrOx 的（共）聚合物的特性，旨在促进其在生物医学领域的巨大潜力。收集了关于修改可能性、结构-性能关系和应用的信息，