Abstract

The formation of C-N bonds is an essential step in the synthesis of many pharmaceutical drugs. In the present study, diversified novel substituted Piperazin-1-yl-7H-pyrrolo[2,3-d] pyrimidines are synthesized via Buchwald Hartwig coupling reaction using Tetrakis(triphenylphosphine)palladium(0) as a catalyst and cesium carbonate as a base. All the synthesized compounds were purified by a simple workup procedure and without column chromatography. All these compounds demonstrated a good to excellent yield and were characterized by ¹H NMR, ¹³C NMR, DEFT-135 NMR, FT-IR, Elemental analysis (CHNS) and Mass spectral studies.

摘要

CN 键的形成是许多药物合成中必不可少的步骤。本研究以四(三苯基膦)钯(0)为催化剂，以碳酸铯为碱，通过Buchwald Hartwig偶联反应合成了多种新型取代哌嗪-1-基-7H-吡咯并[2,3-d]嘧啶。 . 所有合成的化合物均通过简单的后处理程序纯化，无需柱层析。所有这些化合物都表现出良好到极好的产率，并通过¹ H NMR、¹³ C NMR、DEFT-135 NMR、FT-IR、元素分析 (CHNS) 和质谱研究对其进行了表征。