基于肿瘤微环境靶向和调节的肿瘤微血管正常化,Nanoscale

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基于肿瘤微环境靶向和调节的肿瘤微血管正常化
Nanoscale ( IF 5.8 ) Pub Date : 2021-09-24 , DOI: 10.1039/d1nr03387e
Zhipeng Li ₁ , Fang Ning ₁ , Changduo Wang ₁ , Hongli Yu ₁ , Qingming Ma ₁ , Yong Sun ₁

Affiliation

血管生成是肿瘤发展的重要过程。由于促血管生成和抗血管生成因子的失衡，肿瘤血管系统具有曲折、高渗透性和压缩力的特点，导致传统化疗和放疗的效果降低。抗血管生成已成为一种有前景的癌症治疗策略。然而，肿瘤血管生成已被证明是一个复杂的过程，其中肿瘤微环境 (TME) 在肿瘤微血管系统的启动和发展中起着至关重要的作用。TME 中的宿主基质细胞，如癌症相关成纤维细胞 (CAF)、肿瘤相关巨噬细胞 (TAM) 和 Treg 细胞，有助于血管生成。此外，异常代谢环境，如缺氧和酸中毒，导致血管生成因子的上调表达。事实上，肿瘤微血管系统的正常化通过靶向和调节 TME 已成为抗血管生成和抗肿瘤治疗的一种有前景的策略。在这篇综述中，我们总结了肿瘤微血管系统的异常、由异常代谢环境和宿主基质细胞引起的肿瘤血管生成，以及通过靶向和使肿瘤正常化来恢复促血管生成因子和抗血管生成因子之间的平衡的药物递送疗法。 TME 中的脉管系统。

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Normalization of the tumor microvasculature based on targeting and modulation of the tumor microenvironment

Angiogenesis is an essential process for tumor development. Owing to the imbalance between pro- and anti-angiogenic factors, the tumor vasculature possesses the characteristics of tortuous, hyperpermeable vessels and compressive force, resulting in a reduction in the effect of traditional chemotherapy and radiotherapy. Anti-angiogenesis has emerged as a promising strategy for cancer treatment. Tumor angiogenesis, however, has been proved to be a complex process in which the tumor microenvironment (TME) plays a vital role in the initiation and development of the tumor microvasculature. The host stromal cells in the TME, such as cancer associated fibroblasts (CAFs), tumor associated macrophages (TAMs) and Treg cells, contribute to angiogenesis. Furthermore, the abnormal metabolic environment, such as hypoxia and acidosis, leads to the up-regulated expression of angiogenic factors. Indeed, normalization of the tumor microvasculature via targeting and modulating the TME has become a promising strategy for anti-angiogenesis and anti-tumor therapy. In this review, we summarize the abnormalities of the tumor microvasculature, tumor angiogenesis induced by an abnormal metabolic environment and host stromal cells, as well as drug delivery therapies to restore the balance between pro- and anti-angiogenic factors by targeting and normalizing the tumor vasculature in the TME.

更新日期：2021-10-15

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