Development and Advantages of Biodegradable PHA Polymers Based on Electrospun PHBV Fibers for Tissue Engineering and Other Biomedical Applications,ACS Biomaterials Science & Engineering

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Development and Advantages of Biodegradable PHA Polymers Based on Electrospun PHBV Fibers for Tissue Engineering and Other Biomedical Applications
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2021-10-14 , DOI: 10.1021/acsbiomaterials.1c00757
Łukasz Kaniuk ₁ , Urszula Stachewicz ₁

Affiliation

Biodegradable polymeric biomaterials offer a significant advantage in disposable or fast-consuming products in medical applications. Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) is an example of a polyhydroxyalkanoate (PHA), i.e., one group of natural polyesters that are byproducts of reactions taking place in microorganisms in conditions with an excess carbon source. PHA polymers are a promising material for the production of everyday materials and biomedical applications. Due to the high number of monomers in the group, PHAs permit modifications enabling the production of copolymers of different compositions and with different proportions of individual monomers. In order to change and improve the properties of polymer fibers, PHAs are combined with either other natural and synthetic polymers or additives of inorganic phases. Importantly, electrospun PHBV fibers and mats showed an enormous potential in both the medical field (tissue engineering scaffolds, plasters, wound healing, drug delivery systems) and industrial applications (filter systems, food packaging). This Review summarizes the current state of the art in processing PHBV, especially by electrospinning, its degradation processes, and biocompatibility studies, starting from a general introduction to the PHA group of polymers.

中文翻译：

基于电纺 PHBV 纤维的可生物降解 PHA 聚合物的开发和优势，用于组织工程和其他生物医学应用

可生物降解的聚合物生物材料在医疗应用中的一次性或快速消费产品中具有显着优势。聚（3-羟基丁酸酯）-3-羟基戊酸酯 (PHBV) 是聚羟基链烷酸酯 (PHA) 的一个例子，即一组天然聚酯，它们是在具有过量碳源的条件下在微生物中发生的反应的副产物。PHA 聚合物是用于生产日常材料和生物医学应用的有前途的材料。由于该组中的单体数量众多，PHA 允许进行改性，从而能够生产具有不同组成和不同比例的单个单体的共聚物。为了改变和改善聚合物纤维的性能，PHA 与其他天然和合成聚合物或无机相添加剂结合使用。重要的是，电纺 PHBV 纤维和垫子在医学领域（组织工程支架、石膏、伤口愈合、药物输送系统）和工业应用（过滤系统、食品包装）。本综述总结了目前处理 PHBV 的最新技术，特别是通过静电纺丝、其降解过程和生物相容性研究，从对 PHA 聚合物组的一般介绍开始。

更新日期：2021-12-13

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