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Catalytic Control of Spiroketal Formation in Rubromycin Polyketide Biosynthesis
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2021-10-15 , DOI: 10.1002/anie.202109384
Marina Toplak 1 , Raspudin Saleem-Batcha 2 , Jörn Piel 3 , Robin Teufel 1
Affiliation  

Structural snapshots and mechanistic investigation of a key spiroketal synthase provide insights into extensive oxidative backbone rearrangements and spiroketal pharmacophore assembly in rubromycin biosynthesis.
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中文翻译:

红霉素聚酮生物合成中螺旋缩酮形成的催化控制

关键螺旋缩酮合酶的结构快照和机理研究提供了对红霉素生物合成中广泛的氧化骨架重排和螺旋缩酮药效团组装的见解。
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更新日期:2021-12-13
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