Bioinspired Perfluorocarbon-Based Oxygen Carriers with Concave Shape and Deformable Shell,Advanced Materials Technologies

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Bioinspired Perfluorocarbon-Based Oxygen Carriers with Concave Shape and Deformable Shell
Advanced Materials Technologies ( IF 6.4 ) Pub Date : 2021-10-10 , DOI: 10.1002/admt.202100573
Xiaoting Fu ₁ , Seiichi Ohta _{1,

2,

3} , Takahiro Kawakatsu ₄ , Masamichi Kamihira ₅ , Yasuyuki Sakai _{1,

3} , Taichi Ito _{1,

2,

3}

Affiliation

Human red blood cells (hRBCs) possess a unique biconcave structure with a highly deformable cell membrane and condensed cytosol hemoglobin for oxygen delivery. Inspired by hRBCs, novel deformable core-shell particles are developed as perfluorocarbon-based oxygen carriers (OCs), called “cDFCs” (concave-shaped deformable PFC-based OCs), using the Shirasu porous glass (SPG) membrane emulsification technique. cDFCs have a perfluorooctyl bromide core of high oxygen solubility and poly(lactide-co-caprolactone) shell, which is thin and highly deformable. They have an optical equivalent diameter of 7.9 ± 2.5 µm and a unique concave shape. Owing to their low Young's modulus (93 kPa) and their diameter and shape, they successfully pass through a 4.5-µm-gap silicon microchannel as a blood capillary model. Enhanced oxygen supply to multiple layered cells is demonstrated under hypoxic conditions, indicating their efficiency as OCs. cDFCs are new potential OCs in tissue engineering and blood substitution in the future.

中文翻译：

具有凹形和可变形外壳的仿生全氟化碳载氧体

人类红细胞 (hRBCs) 具有独特的双凹结构，具有高度可变形的细胞膜和用于氧气输送的浓缩细胞溶质血红蛋白。受 hRBC 的启发，使用 Shirasu 多孔玻璃 (SPG) 膜乳化技术开发了新型可变形核壳颗粒作为全氟化碳基氧载体 (OC)，称为“cDFC”（凹形可变形 PFC 基 OC）。cDFC 具有高氧溶解度的全氟辛基溴核和聚（丙交酯）-己内酯）壳，它很薄且高度可变形。它们具有 7.9 ± 2.5 µm 的光学等效直径和独特的凹面形状。由于它们的低杨氏模量 (93 kPa) 及其直径和形状，它们成功地通过了 4.5 µm 间隙的硅微通道作为毛细血管模型。在缺氧条件下证明了对多层细胞的供氧增强，表明它们作为 OC 的效率。cDFCs是未来组织工程和血液替代中新的潜在OCs。

更新日期：2021-10-10

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