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Total Synthesis of Glipizide and Glibenclamide in Continuous Flow
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2021-10-11 , DOI: 10.1002/chem.202103196 Cloudius R Sagandira 1 , Agnes Z Khasipo 1 , Paul Watts 1
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2021-10-11 , DOI: 10.1002/chem.202103196 Cloudius R Sagandira 1 , Agnes Z Khasipo 1 , Paul Watts 1
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Glipizide and glibenclamide remain some of the widely prescribed antidiabetic sulfonylurea drugs for the treatment of type 2 diabetes mellitus. Semi-telescoped continuous flow synthesis of both glipizide and glibenclamide are demonstrated herein which is accompanied by an overall yield of 80–85 % within 10 min total residence time.
中文翻译：
格列吡嗪和格列本脲的连续流动全合成
格列吡嗪和格列本脲仍然是一些广泛用于治疗 2 型糖尿病的抗糖尿病磺脲类药物。本文展示了格列吡嗪和格列本脲的半伸缩连续流动合成，在 10 分钟总停留时间内总产率为 80-85%。
更新日期：2021-11-17
中文翻译：
格列吡嗪和格列本脲的连续流动全合成
格列吡嗪和格列本脲仍然是一些广泛用于治疗 2 型糖尿病的抗糖尿病磺脲类药物。本文展示了格列吡嗪和格列本脲的半伸缩连续流动合成，在 10 分钟总停留时间内总产率为 80-85%。
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