PDMS-Parylene 混合、柔性微 ECoG 电极阵列用于多皮质脑区癫痫电生理活动的时空映射,ACS Applied Bio Materials

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PDMS-Parylene 混合、柔性微 ECoG 电极阵列用于多皮质脑区癫痫电生理活动的时空映射
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2021-10-09 , DOI: 10.1021/acsabm.1c00923
Xinrong Li _{1,

2} , Yilin Song _{1,

2} , Guihua Xiao _{1,

2} , Enhui He _{1,

2} , Jingyu Xie _{1,

2} , Yuchuan Dai _{1,

2} , Yu Xing _{1,

2} , Yun Wang _{1,

2} , Yiding Wang _{1,

2} , Shengwei Xu _{1,

2} , Mixia Wang _{1,

2} , Tiger H Tao ₃ , Xinxia Cai _{1,

2}

Affiliation

癫痫检测和病灶定位是癫痫研究中亟待解决的问题。皮质顺应性和精细空间精度皮质电图 (ECoG) 传感器阵列，特别是用于实时检测多皮质功能区域和描绘癫痫病灶仍然是一个挑战。在这里，我们制造了聚二甲基硅氧烷 (PDMS)-聚对二甲苯混合的柔性微型 ECoG 电极阵列。多壁碳纳米管（MWCNTs）/聚（3,4-乙烯二氧噻吩）：聚（苯乙烯磺酸盐）（PEDOT：PSS）纳米复合改性电极界面显着提高了低阻抗（20.68±6.65 kΩ）的传感性能，稳定的相位偏移, 灵敏度高。多皮质脑区（体感皮层、顶叶联合皮层、和视觉皮层）在正常和癫痫状态下同时监测。癫痫ECoG活动从起点向相邻皮层时空传播。观察到波形、功率和频带的显着变化。正常状态下的ECoG电位（123±23μV）在尖峰波阶段显着高达417±87μV。此外，癫痫活动的功率（11.049 ± 4.513 μW）是正常活动的功率（1.092 ± 0.369 μW）的 10 倍。此外，发现θ频带是癫痫信号的特征频带。这些多皮质区域的联合分析结果表明，顶叶联合皮质上活跃的微米级区域更可能是癫痫病灶。具有高空间细节的皮质映射提供了对病变的准确描绘。灵活的微 ECoG 电极阵列是构建皮质时空图的有力工具。它为癫痫病灶定位、生物医学诊断和脑机交互提供了一个技术平台。

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PDMS–Parylene Hybrid, Flexible Micro-ECoG Electrode Array for Spatiotemporal Mapping of Epileptic Electrophysiological Activity from Multicortical Brain Regions

Epilepsy detection and focus location are urgent issues that need to be solved in epilepsy research. A cortex conformable and fine spatial accuracy electrocorticogram (ECoG) sensor array, especially for real-time detection of multicortical functional regions and delineating epileptic focus remains a challenge. Here, we fabricated a polydimethylsiloxane (PDMS)–parylene hybrid, flexible micro-ECoG electrode array. The multiwalled carbon nanotubes (MWCNTs)/poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) nanocomposite-modified electrode interface significantly improved the sensing performance with low impedance (20.68 ± 6.65 kΩ), stable phase offset, and high sensitivity. The electrophysiological activities of multicortical brain regions (somatosensory cortex, parietal association cortex, and visual cortex) were simultaneously monitored during normal and epileptic statuses. The epileptic ECoG activities spread spatiotemporally from the starting point toward the adjacent cortex. Significant variations of the waveform, power, and frequency band were observed. The ECoG potential (123 ± 23 μV) at normal status was prominently up to 417 ± 87 μV at the spike wave stage. Besides, the power for epileptic activity (11.049 ± 4.513 μW) was 10 times higher than that (1.092 ± 0.369 μW) for normal activity. In addition, the theta frequency band was found to be a characteristic frequency band of epileptic signals. These joint analysis results of multicortical regions indicated that the active micron-scale region on the parietal association cortex was more likely to be the epileptogenic focus. Cortical mapping with high spatial detail provides the accurate delineation of lesions. The flexible micro-ECoG electrode array is a powerful tool for constructing a spatiotemporal map of the cortex. It provides a technical platform for epileptic focus location, biomedical diagnosis, and brain–computer interaction.

更新日期：2021-11-15

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