Mechanism of Anosmia Caused by Symptoms of COVID-19 and Emerging Treatments,ACS Chemical Neuroscience

当前位置： X-MOL 学术 › ACS Chem. Neurosci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Mechanism of Anosmia Caused by Symptoms of COVID-19 and Emerging Treatments
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2021-10-05 , DOI: 10.1021/acschemneuro.1c00477
Raziyeh Najafloo ₁ , Jila Majidi ₁ , Alimohamad Asghari ₂ , Mina Aleemardani ₃ , Seyed Kamran Kamrava ₄ , Sara Simorgh ₁ , Amelia Seifalian _{5,

6} , Zohreh Bagher _{1,

4} , Alexander M Seifalian ₇

Affiliation

The occurrence of anosmia, the loss or change in sense of smell, is one of the most common symptoms of COVID-19 experienced by almost 53% of those affected. Several hypotheses explain the mechanism of anosmia in patients suffering from COVID-19. This study aims to review the related mechanisms and answer the questions regarding COVID-19-related anosmia as well as propose a new strategy for treatment of long-term anosmia as a result of COVID-19 infection. This paper covers all of the studies investigating olfactory disorders following COVID-19 infection and explains the possible reasons for the correlated anosmia, including olfactory cleft syndrome, local inflammation in the nasal epithelium, early apoptosis of olfactory cells, changes in olfactory cilia and odor transmission, damage to microglial cells, effect on olfactory bulbs, epithelial olfactory injury, and impairment of olfactory neurons and stem cells. The key questions that arise in this field have been discussed, such as why prevalent anosmia is varied among the age categories and among sexes and the correlation of anosmia with mild or severe COVID-19 infection. The angiotensin-converting enzyme 2 receptor is a significant player in the mechanism of anosmia in COVID-19 patients. Based on current studies, a novel approach to treat long-COVID-19 with ongoing anosmia has been proposed. The fields of smart drug delivery, tissue engineering, and cell therapy provide a hypothesized strategy that can minimize the side effects of current treatments and support efficient recovery of the olfactory system.

中文翻译：

COVID-19 症状引起的嗅觉丧失的机制和新兴治疗方法

嗅觉丧失（嗅觉丧失或改变）是 COVID-19 最常见的症状之一，近 53% 的受影响者经历过这种症状。几种假设解释了 COVID-19 患者嗅觉丧失的机制。本研究旨在回顾相关机制并回答与 COVID-19 相关的嗅觉丧失的问题，并提出治疗因 COVID-19 感染而导致的长期嗅觉丧失的新策略。本文涵盖了所有调查 COVID-19 感染后嗅觉障碍的研究，并解释了相关嗅觉丧失的可能原因，包括嗅裂综合征、鼻上皮局部炎症、嗅觉细胞的早期凋亡、嗅觉纤毛的变化和气味传播、小胶质细胞损伤、嗅球影响、上皮嗅觉损伤以及嗅觉神经元和干细胞损伤。讨论了该领域出现的关键问题，例如为什么不同年龄组和性别之间普遍存在嗅觉缺失症，以及嗅觉缺失症与轻度或重度 COVID-19 感染的相关性。血管紧张素转换酶 2 受体在 COVID-19 患者嗅觉丧失机制中发挥着重要作用。根据目前的研究，提出了一种治疗长期 COVID-19 持续性嗅觉丧失的新方法。智能药物输送、组织工程和细胞治疗领域提供了一种假设策略，可以最大限度地减少当前治疗的副作用并支持嗅觉系统的有效恢复。

更新日期：2021-10-20

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南