2,2,2-trifluoroethanol (TFE) is used more and more widely in industry, but there are few reports on its separation at present. The purpose of this work is to explore the feasibility of separating 2,2,2-trifluoroethanol from aqueous solution using different extractants, as isopentanol, 2-Ethyl-1-hexanol, n-Propyl acetate, and dichloromethane. The liquid–liquid equilibrium data of TFE + water +{isopentanol or 2-ethyl-1-hexanol or n-propyl acetate or dichloromethane} at standard pressure and 303.2 K were measured. The estimated partition coefficient (D) and separation factor (S) of TFE are higher than 1. Meanwhile, Othmer-Tobias and Hand's empirical equations verified the experimental data's consistency, and the squares of its linear correlation are all greater than 0.99. The NRTL and UNIQUAC activity coefficient models were used to correlate the experimental data, and different model parameters were obtained by regression. After comparing the calculated values of the model with the experimental data, it was found that the root means square deviation (RMSD%) was less than 0.34%, which indicate that both models have a reasonable correlation with the experimental data of the ternary system and can accurately predict the experimental data.

2,2,2-三氟乙醇（TFE）在工业上的应用越来越广泛，但目前对其分离的报道较少。这项工作的目的是探索使用不同的萃取剂（如异戊醇、2-乙基-1-己醇、乙酸正丙酯和二氯甲烷）从水溶液中分离 2,2,2-三氟乙醇的可行性。测量了标准压力和 303.2 K 下 TFE + 水 +{异戊醇或 2-乙基-1-己醇或乙酸正丙酯或二氯甲烷}的液-液平衡数据。估计的分配系数 ( D ) 和分离因子 ( S)的TFE均大于1。同时，Othmer-Tobias和Hand的经验方程验证了实验数据的一致性，其线性相关的平方均大于0.99。采用NRTL和UNIQUAC活动系数模型对实验数据进行关联，通过回归得到不同的模型参数。将模型的计算值与实验数据进行对比，发现均方根偏差（RMSD%）小于0.34%，说明两种模型与三元系统的实验数据具有合理的相关性，能准确预测实验数据。