当前位置:
X-MOL 学术
›
J. Clin. Lab. Anal.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Dihydropyrimidine dehydrogenase (DPYD) gene c.1627A>G A/G and G/G genotypes are risk factors for lymph node metastasis and distant metastasis of colorectal cancer
Journal of Clinical Laboratory Analysis ( IF 2.6 ) Pub Date : 2021-10-06 , DOI: 10.1002/jcla.24023
Juanzi Zeng 1, 2 , Heming Wu 2, 3 , Qingyan Huang 2, 3 , Jiaquan Li 1, 2 , Zhikang Yu 2, 3 , Zhixiong Zhong 2, 3
Journal of Clinical Laboratory Analysis ( IF 2.6 ) Pub Date : 2021-10-06 , DOI: 10.1002/jcla.24023
Juanzi Zeng 1, 2 , Heming Wu 2, 3 , Qingyan Huang 2, 3 , Jiaquan Li 1, 2 , Zhikang Yu 2, 3 , Zhixiong Zhong 2, 3
Affiliation
![]() |
Dihydropyrimidine dehydrogenase (DPD) acts as the key enzyme catabolizing pyrimidines, and may affect the tumor progression. DPYD gene mutations affect DPD activity. The relationship between DPYD IVS14+1G>A, c.1627A>G, c.85T>C and lymph node metastasis (LNM) and distant metastasis (DM) of colorectal cancer (CRC) was investigated.
中文翻译:
二氢嘧啶脱氢酶(DPYD)基因c.1627A>GA/G和G/G基因型是结直肠癌淋巴结转移和远处转移的危险因素
二氢嘧啶脱氢酶 (DPD) 是嘧啶分解代谢的关键酶,可能影响肿瘤进展。DPYD基因突变影响DPD活性。探讨了DPYD IVS14+1G>A、c.1627A>G、c.85T>C与结直肠癌(CRC)淋巴结转移(LNM)和远处转移(DM)的关系。
更新日期:2021-11-20
中文翻译:

二氢嘧啶脱氢酶(DPYD)基因c.1627A>GA/G和G/G基因型是结直肠癌淋巴结转移和远处转移的危险因素
二氢嘧啶脱氢酶 (DPD) 是嘧啶分解代谢的关键酶,可能影响肿瘤进展。DPYD基因突变影响DPD活性。探讨了DPYD IVS14+1G>A、c.1627A>G、c.85T>C与结直肠癌(CRC)淋巴结转移(LNM)和远处转移(DM)的关系。