Bio-Inspired Bimetallic Enzyme Mimics as Bio-Orthogonal Catalysts for Enhanced Bacterial Capture and Inhibition,Chemistry of Materials

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Bio-Inspired Bimetallic Enzyme Mimics as Bio-Orthogonal Catalysts for Enhanced Bacterial Capture and Inhibition
Chemistry of Materials ( IF 7.2 ) Pub Date : 2021-10-04 , DOI: 10.1021/acs.chemmater.1c02469
Jingsheng Niu _{1,

2} , Chuanqi Zhao _{1,

2} , Chun Liu _{1,

2} , Jinsong Ren _{1,

2} , Xiaogang Qu _{1,

2}

Affiliation

Bacterial infections present a major threat to global health every year. The antibiotic treatment can easily lead to multidrug resistance. Despite great efforts devoted to improving the activity of the existing antibiotics or developing new antibiotics, the innate ability of bacteria to develop resistance has exceeded the rate of development of new antibiotics, which indicates that strategies to develop long-term antimicrobial therapies are ultimately doomed to fail. Therefore, it is very important to develop new ways to fight bacteria. Inspired by recent advances on nanotechnology and in vivo bio-orthogonal chemistry, here we design and synthesize biomimetic sea urchin-like PdCu nanoparticles for antibacterial therapy. The multibranched structure of PdCu-Urchin shows excellent bacteria adhesion ability. Due to the peroxidase mimetic activity and click catalysis activity of PdCu-Urchin, it possesses excellent antibacterial ability in the presence of H₂O₂ and precursor molecules. Together, the increased interactions between PdCu-Urchin and bacteria ensure that the active molecules and high-toxicity reactive oxygen species (ROS) can effectively act on the bacteria in situ after capturing bacteria. Both in vitro and in vivo antibacterial experiments show that our design has great potential in solving the problem of the limited ROS transmission distance in antibacterial therapy and decreasing overuse of antibiotics to avoid drug resistance. This work provides new insights for antibacterial therapy by integrating nanotopology and synergistic bio-orthogonal in vivo drug synthesis.

中文翻译：

仿生双金属酶模拟物作为生物正交催化剂用于增强细菌捕获和抑制

细菌感染每年都对全球健康构成重大威胁。抗生素治疗很容易导致多药耐药。尽管为提高现有抗生素的活性或开发新抗生素付出了巨大努力，但细菌产生耐药性的先天能力已经超过了新抗生素的开发速度，这表明开发长期抗菌疗法的策略最终注定要失败。失败。因此，开发新的方法来对抗细菌是非常重要的。受纳米技术和体内生物正交化学最新进展的启发，我们设计并合成了仿生海胆状 PdCu 纳米颗粒用于抗菌治疗。PdCu-Urchin 的多分支结构显示出优异的细菌粘附能力。₂ O ₂和前体分子。总之，PdCu-海胆与细菌之间增加的相互作用确保活性分子和高毒性活性氧（ROS）在捕获细菌后可以有效地原位作用于细菌。体外和体内抗菌实验表明，我们的设计在解决抗菌治疗中ROS传输距离有限的问题和减少抗生素的过度使用以避免耐药性方面具有巨大潜力。这项工作通过整合纳米拓扑和协同生物正交体内药物合成为抗菌治疗提供了新的见解。

更新日期：2021-10-26

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