Although the toxicity of bisphenol S has been studied in some species, the global metabolic network disrupted by bisphenol S remains unclear. To this end, published datasets related to the genes, proteins, and metabolites disturbed by bisphenol S were investigated through omics methods. The dataset revealed that bisphenol S at high concentrations tended to downregulate biomolecules, while low concentrations of bisphenol S tended to enhance metabolic reactions. The results showed that exposure to bisphenol S upregulated estrogen and downregulated androgen metabolism in humans, mice, rats, and zebrafish. Fatty acid metabolism and phospholipid metabolism in mice were upregulated. Reactions in amino acid metabolism were upregulated, with the exception of the suppressive conversion of arginine to ornithine. In zebrafish, fatty acid synthesis was promoted, while nucleotide metabolism was primarily depressed through the downregulation of pyruvate 2-o-phosphotransferase. The interference in amino acid metabolism by bisphenol S could trigger Alzheimer’s disease, while its disturbance of glucose metabolism was associated with type II diabetes. Disturbed glycolipid metabolism and vitamin metabolism could induce Alzheimer’s disease and diabetes. These findings based on omics data provide scientific insight into the metabolic network regulated by bisphenol S and the diseases triggered by its metabolic disruption.

尽管已经在某些物种中研究了双酚 S 的毒性，但双酚 S 破坏的全球代谢网络仍不清楚。为此，通过组学方法研究了与双酚 S 干扰的基因、蛋白质和代谢物相关的已发表数据集。数据集显示，高浓度的双酚 S 倾向于下调生物分子，而低浓度的双酚 S 倾向于增强代谢反应。结果表明，暴露于双酚 S 会上调人类、小鼠、大鼠和斑马鱼的雌激素代谢并下调雄激素代谢。小鼠的脂肪酸代谢和磷脂代谢上调。除了精氨酸向鸟氨酸的抑制性转化外，氨基酸代谢中的反应被上调。在斑马鱼中，脂肪酸合成得到促进，而核苷酸代谢主要通过丙酮酸 2-o-磷酸转移酶的下调而受到抑制。双酚S对氨基酸代谢的干扰可引发阿尔茨海默病，而其对葡萄糖代谢的干扰与II型糖尿病有关。糖脂代谢和维生素代谢紊乱可诱发阿尔茨海默病和糖尿病。这些基于组学数据的发现提供了对双酚 S 调节的代谢网络及其代谢中断引发的疾病的科学洞察。而其糖代谢紊乱与II型糖尿病有关。糖脂代谢和维生素代谢紊乱可诱发阿尔茨海默病和糖尿病。这些基于组学数据的发现提供了对双酚 S 调节的代谢网络及其代谢中断引发的疾病的科学洞察。而其糖代谢紊乱与II型糖尿病有关。糖脂代谢和维生素代谢紊乱可诱发阿尔茨海默病和糖尿病。这些基于组学数据的发现提供了对双酚 S 调节的代谢网络及其代谢中断引发的疾病的科学洞察。