Drug Delivery and Translational Research ( IF 5.7 ) Pub Date : 2021-10-05 , DOI: 10.1007/s13346-021-01071-9 Mori Dhaval 1 , Poonam Vaghela 1 , Kajal Patel 1 , Keshvi Sojitra 1 , Mohini Patel 1 , Sushma Patel 1 , Kiran Dudhat 2 , Sunny Shah 1 , Ravi Manek 1 , Ramesh Parmar 1
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Lipid-based emulsion system — a subcategory of emulsion technology, has emerged as an enticing option to improve the solubility of the steadily rising water-insoluble candidates. Along with enhancing solubility, additional advantages such as improvement in permeability, protection against pre-systemic metabolism, ease of manufacturing, and easy to scale-up have made lipid-based emulsion technology very popular among academicians and manufacturers. The present article provides a comprehensive review regarding various critical properties of lipid-based emulsion systems, such as microemulsion, nanoemulsion, SMEDDS (self microemulsifying drug delivery system), and SNEDDS (self nanoemulsifying drug delivery system). The present article also explains in detail the similarities and differences between them, the stabilization mechanism, methods of preparation, excipients used to prepare them, and evaluation techniques. Subtle differences between nearly related terminologies such as microemulsion and nanoemulsion, SMEDDS, and SNEDDS are also explained in detail to clarify the basic differences. The present article also gives in-depth information regarding the chemical structure of various lipidic excipients, various possible chemical modifications to modify their inherent properties, and their regulatory status for rational selection.
Graphical abstract
中文翻译：
基于脂质的乳液给药系统——综合综述
基于脂质的乳液系统——乳液技术的一个子类别，已成为提高稳步上升的水不溶性候选物溶解度的诱人选择。除了提高溶解度外，其他优点，如改善渗透性、防止系统前代谢、易于制造和易于放大，使得基于脂质的乳液技术在院士和制造商中非常受欢迎。本文对基于脂质的乳液系统的各种关键特性进行了全面综述，例如微乳液、纳米乳液、SMEDDS（自微乳化药物递送系统）和 SNEDDS（自纳米乳化药物递送系统）。本文还详细解释了它们之间的异同，稳定机制，制备方法、用于制备它们的赋形剂和评估技术。还详细解释了几乎相关的术语（例如微乳液和纳米乳液、SMEDDS 和 SNEDDS）之间的细微差异，以阐明基本差异。本文还深入介绍了各种脂质赋形剂的化学结构、各种可能的化学修饰以改变其固有特性，以及它们的合理选择监管状态。
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