Discovery of Glycosyltransferases Involved in the Biosynthesis of Ligupurpuroside B,Organic Letters

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Discovery of Glycosyltransferases Involved in the Biosynthesis of Ligupurpuroside B
Organic Letters ( IF 4.9 ) Pub Date : 2021-10-05 , DOI: 10.1021/acs.orglett.1c02873
Yihan Yang _{1,

2} , Yanan Wu _{1,

3} , Yibin Zhuang ₁ , Tao Liu ₁

Affiliation

In this study, we report the characterization of three glycosyltransferases involved in the biosynthesis of ligupurpuroside B, a complex acylated phenolic glycoside in Ligustrum robustum. UGT85AF8 catalyzed the formation of salidroside from tyrosol. UGT79G7, an osmanthuside A 1,3-rhamnosyltransferase, and UGT79A19, an osmanthuside B 1,4-rhamnosyltransferase, sequentially converted osmanthuside A into ligupurpuroside B. Orthologs of UGT79G7 were also discovered from other plants producing verbascoside. These rhamnosyltransferases expand the toolbox for the biosynthesis of natural products with various sugar chains.

中文翻译：

发现参与 Ligupurpuroside B 生物合成的糖基转移酶

在这项研究中，我们报告了参与 ligupurpuroside B 生物合成的三种糖基转移酶的表征，这是一种在女贞子中复杂的酰化酚糖苷。UGT85AF8 催化酪醇形成红景天苷。UGT79G7（一种桂花苷 A 1,3-鼠李糖基转移酶）和 UGT79A19（一种桂花苷 B 1,4-鼠李糖基转移酶）依次将桂花苷 A 转化为 ligupurpuroside B。还在其他生产马鞭草的植物中发现了 UGT79G7 的直系同源物。这些鼠李糖基转移酶扩展了生物合成具有各种糖链的天然产物的工具箱。

更新日期：2021-10-15

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