当前位置: X-MOL 学术NMR Biomed. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Whole-brain high-resolution metabolite mapping with 3D compressed-sensing SENSE low-rank 1H FID-MRSI
NMR in Biomedicine ( IF 2.7 ) Pub Date : 2021-10-01 , DOI: 10.1002/nbm.4615
Antoine Klauser 1, 2 , Paul Klauser 3, 4 , Frédéric Grouiller 5, 6 , Sébastien Courvoisier 1, 2 , François Lazeyras 1, 2
Affiliation  

There is a growing interest in the neuroscience community to map the distribution of brain metabolites in vivo. Magnetic resonance spectroscopic imaging (MRSI) is often limited by either a poor spatial resolution and/or a long acquisition time, which severely restricts its applications for clinical and research purposes. Building on a recently developed technique of acquisition-reconstruction for 2D MRSI, we combined a fast Cartesian 1H-FID-MRSI acquisition sequence, compressed-sensing acceleration, and low-rank total-generalized-variation constrained reconstruction to produce 3D high-resolution whole-brain MRSI with a significant acquisition time reduction. We first evaluated the acceleration performance using retrospective undersampling of a fully sampled dataset. Second, a 20 min accelerated MRSI acquisition was performed on three healthy volunteers, resulting in metabolite maps with 5 mm isotropic resolution. The metabolite maps exhibited the detailed neurochemical composition of all brain regions and revealed parts of the underlying brain anatomy. The latter assessment used previous reported knowledge and a atlas-based analysis to show consistency of the concentration contrasts and ratio across all brain regions. These results acquired on a clinical 3 T MRI scanner successfully combined 3D 1H-FID-MRSI with a constrained reconstruction to produce detailed mapping of metabolite concentrations at high resolution over the whole brain, with an acquisition time suitable for clinical or research settings.

中文翻译:

具有 3D 压缩传感 SENSE 低秩 1H FID-MRSI 的全脑高分辨率代谢物作图

神经科学界对绘制体内脑代谢物分布图的兴趣日益浓厚。磁共振光谱成像 (MRSI) 通常受到空间分辨率差和/或采集时间长的限制,这严重限制了其在临床和研究目的中的应用。基于最近开发的 2D MRSI 采集重建技术,我们结合了快速笛卡尔1H-FID-MRSI 采集序列、压缩感知加速和低秩总广义变化约束重建,以产生 3D 高分辨率全脑 MRSI,显着减少采集时间。我们首先使用全采样数据集的回顾性欠采样来评估加速性能。其次,对三名健康志愿者进行了 20 分钟的加速 MRSI 采集,得到了具有 5 mm 各向同性分辨率的代谢物图。代谢物图展示了所有大脑区域的详细神经化学成分,并揭示了部分潜在的大脑解剖结构。后一种评估使用先前报告的知识和基于图谱的分析来显示所有大脑区域的浓度对比和比率的一致性。1 H-FID-MRSI 具有约束重建功能,可在整个大脑中以高分辨率生成代谢物浓度的详细映射,采集时间适合临床或研究环境。
更新日期:2021-10-01
down
wechat
bug