Continuous theta burst TMS of area MT+ impairs attentive motion tracking,European Journal of Neuroscience

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Continuous theta burst TMS of area MT+ impairs attentive motion tracking
European Journal of Neuroscience ( IF 2.7 ) Pub Date : 2021-09-30 , DOI: 10.1111/ejn.15480
Arijit Chakraborty _{1,

2} , Tiffany T. Tran ₁ , Andrew E. Silva ₁ , Deborah Giaschi ₃ , Benjamin Thompson _{1,

4,

5}

Affiliation

Attentive motion tracking deficits measured using multiple object tracking (MOT) tasks have been identified in a number of neurodevelopmental disorders such as amblyopia and autism. These deficits are often attributed to the abnormal development of high-level attentional networks. However, neuroimaging evidence from amblyopia suggests that reduced MOT performance can be explained by impaired function in motion-sensitive area MT+ alone. To test the hypothesis that a subtle disruption of MT+ function could cause MOT impairment, we assessed whether continuous theta burst stimulation (cTBS) of MT+ influenced MOT task accuracy in individuals with normal vision. The MOT stimulus consisted of four target and four distractor dots and was presented at ±10° eccentricity (right/left hemifield). fMRI-guided cTBS was applied to left MT+. Participants (n = 13, age: 27 ± 3) attended separate active and sham cTBS sessions where the MOT task was completed before, 5-min post- and 30-min post-cTBS. Active cTBS significantly impaired MOT task accuracy relative to baseline for the right (stimulated) hemifield 5-min (10 ± 2% reduction) and 30-min (14 ± 3% reduction) post-stimulation. No impairment occurred within the left (control) hemifield after active cTBS or for either hemifield after sham cTBS. These results highlight the importance of lower level motion processing for MOT, suggesting that a minor disruption of MT+ function alone is sufficient to cause a deficit in MOT performance.

中文翻译：

区域 MT+ 的连续 theta 突发 TMS 会削弱注意力的运动跟踪

已经在许多神经发育障碍（例如弱视和自闭症）中发现了使用多对象跟踪 (MOT) 任务测量的注意力运动跟踪缺陷。这些缺陷通常归因于高级注意力网络的异常发展。然而，来自弱视的神经影像学证据表明，运动敏感区 MT+ 的功能受损可以解释 MOT 性能降低。为了检验 MT+ 功能的细微中断可能导致 MOT 损伤的假设，我们评估了 MT+ 的连续 theta 爆发刺激 (cTBS) 是否影响视力正常个体的 MOT 任务准确性。MOT 刺激由四个目标点和四个牵引点组成，并以 ±10° 偏心（右/左半场）呈现。fMRI 引导的 cTBS 应用于左侧 MT+。参加者（n = 13，年龄：27 ± 3) 参加单独的主动和假 cTBS 会议，其中 MOT 任务在 cTBS 后 5 分钟和 30 分钟后完成。相对于右侧（刺激）半场 5 分钟（减少 10 ± 2%）和刺激后 30 分钟（减少 14 ± 3%），主动 cTBS 显着削弱了 MOT 任务的准确性。活动 cTBS 后的左侧（对照）半场或假 cTBS 后的任一半场均未发生损伤。这些结果强调了较低级别运动处理对 MOT 的重要性，表明仅对 MT+ 功能的轻微破坏就足以导致 MOT 性能出现缺陷。

更新日期：2021-11-10

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