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Synthesis, characterization and antimicrobial evaluation of some novel (3-methyl- 5-((3-phenylisoxazol-5-yl)methoxy)benzofuran-2-yl)(phenyl)methanones
Indian Journal of Chemistry, Section B Pub Date : 2021-09-29
A Kishore Kumar, V Sunitha, P Shankaraiah, P Jalapathi

The synthesis and characterization of a novel class of benzofuran-isoxazole 7a-j hybrid heterocyclic unit are described and their antimicrobial activities evaluated. The antimicrobial investigation studies reveal that the majority of the final target compounds exhibit moderate to excellent activity against tested microbes. Among the compounds screened 7b, 7a and 7i have shown potent activity and compounds 7h, 7c, 7f show good activity compared to standard drugs Gentamicin and Nystatin.

中文翻译:

一些新型(3-甲基-5-((3-苯基异恶唑-5-基)甲氧基)苯并呋喃-2-基)(苯基)甲酮的合成、表征和抗菌评价

描述了一类新型苯并呋喃-异恶唑 7a-j 杂环单元的合成和表征,并评估了它们的抗菌活性。抗菌调查研究表明,大多数最终目标化合物对测试的微生物表现出中等至极好的活性。在筛选的化合物 7b、7a 和 7i 中,与标准药物庆大霉素和制霉菌素相比,化合物 7h、7c、7f 显示出有效的活性。
更新日期:2021-09-29
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