Photosensitizers (PSs) with aggregation-induced emission (AIE) feature show promising applications in fluorescence imaging-guided photodynamic therapy (PDT) in virtue of their enhanced fluorescence and phototoxicity in aggregate state. Seeking the ideal AIE luminogens (AIEgens) with good capability of generating reactive oxygen species is still urgent. Here we rationally synthesized an acceptor-donor-acceptor (A-D-A) structured AIEgen (BTZPP) and then prepared it into nanoparticles (NPs) through a simple re-precipitation procedure. The obtained BTZPP NPs show a deep-red emission peaked at 635 nm, a large Stokes shift of 195 nm, and a high ¹O₂ generation quantum yield of 72.3%. Moreover, these NPs can selectively target lysosomes in live cells and image mouse tumor with a high contrast and long-term tracking (up to 14 days) capability. The high-efficiency imaging-guided PDT against cancer cells and tumors is successfully demonstrated in vitro and in vivo.

具有聚集诱导发射 (AIE) 特性的光敏剂 (PS) 凭借其在聚集态增强的荧光和光毒性，在荧光成像引导的光动力疗法 (PDT) 中显示出有前景的应用。寻找具有良好产生活性氧物种能力的理想AIE发光体（AIEgens）仍然迫在眉睫。在这里，我们合理合成了一种受体-供体-受体（ADA）结构的 AIEgen（BTZPP），然后通过简单的再沉淀程序将其制备成纳米颗粒（NPs）。获得的 BTZPP NPs 在 635 nm 处显示出深红色发射峰值，195 nm 的大斯托克斯位移和高¹ O ₂代量子产率为72.3%。此外，这些 NPs 可以选择性地靶向活细胞中的溶酶体，并以高对比度和长期跟踪（长达 14 天）的能力对小鼠肿瘤进行成像。针对癌细胞和肿瘤的高效成像引导的 PDT 已在体外和体内成功证明。