GTR膜用于牙周再生的材料开发和生物学特性的最新进展,Chemical Biology & Drug Design

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GTR膜用于牙周再生的材料开发和生物学特性的最新进展
Chemical Biology & Drug Design ( IF 3.2 ) Pub Date : 2021-09-28 , DOI: 10.1111/cbdd.13959
Sadaf Ul Hassan _{1,

2} , Bushra Bilal ₂ , Muhammad Shahid Nazir ₂ , Syed Ali Raza Naqvi ₃ , Zufiqar Ali ₄ , Sohail Nadeem ₁ , Nawshad Muhammad ₅ , Bushra Anees ₂ , Aysha Mohyuddin ₁

Affiliation

慢性牙周病是一种非常常见的感染，会引起口腔组织的破坏，对于其治疗，必须尽量减少感染和缺损再生。牙周组织由四种类型的组织组成：(a) 牙骨质、(b) 牙周韧带、(c) 牙龈和 4) 牙槽骨。在分离的腔中，再生过程也允许各种细胞增殖。引导组织再生 (GTR) 是一种有利于牙周再生的潜在程序；但也存在一些局限性（如止血效果不佳、机械性能差、生物降解不当等）。本综述主要强调以下几个方面： (a) 牙周组织及其免疫学情况的概述，(b) 最近使用的特殊牙周组织再生疗法；(c) 市售 GTR 膜概述，以及 GTR 膜材料表征和加工的最新进展；4) 不同的非高分子/高分子材料的功能，它们作为药物载体、抗菌剂、纳米颗粒和牙周屏障膜，以防止牙周炎症和提高 GTR 膜的强度。

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Recent progress in materials development and biological properties of GTR membranes for periodontal regeneration

Chronic periodontal is a very common infection that instigates the destruction of oral tissue, and for its treatment, it is necessary to minimize the infection and the defects regeneration. Periodontium consists of four types of tissues: (a) cementum, (b) periodontal ligament, (c) gingiva, and 4) alveolar bone. In separated cavities, regenerative process also allows various cell proliferations. Guided tissue regeneration (GTR) is a potential procedure that favors periodontal regrowth; however, some limitations (such as ineffective hemostatic property, poor mechanical property, and improper biodegradation) are also associated with it. This review mainly emphasizes on the following areas: (a) a summarized overview of the periodontium and its immunological situations, (b) recently utilized treatments for regeneration of distinctive periodontal tissues; (c) an overview of GTR membranes available commercially, and the latest developments on the characterization and processing of GTR membrane material; and 4) the function of the different non-polymeric/polymeric materials, which are acting as drug carriers, antibacterial agents, nanoparticles, and periodontal barrier membranes to prevent periodontal inflammation and to improve the strength of the GTR membrane.

更新日期：2021-11-25

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