Triptycene derivatives as chiral probes for studying the molecular enantiorecognition on sub-2-μm particle cellulose tris(3,5-dimethylphenylcarbamate) chiral stationary phase,Chirality

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Triptycene derivatives as chiral probes for studying the molecular enantiorecognition on sub-2-μm particle cellulose tris(3,5-dimethylphenylcarbamate) chiral stationary phase
Chirality ( IF 2.8 ) Pub Date : 2021-09-27 , DOI: 10.1002/chir.23358
Alessia Rosetti ₁ , Giovanni Preda ₂ , Claudio Villani ₁ , Marco Pierini ₁ , Dario Pasini ₂ , Roberto Cirilli ₃

Affiliation

Two chiral triptycene derivatives were analyzed on the Chiralpak IB-U column packed with cellulose tris(3,5-dimethylphenylcarbamate)-based sub-2-μm diameter particles. Under normal-phase conditions, sub-minute baseline enantioseparations were obtained. Differences in structural elements and chromatographic behavior of the investigated compounds were evaluated to identify the interactions that drive the chiral discrimination process. From the evaluation of the experimental chromatographic data, it was found that hydrogen bond formation is essential for the separation of enantiomers.

中文翻译：

Triptycene 衍生物作为手性探针，用于研究亚 2-μm 颗粒纤维素三（3,5-二甲基苯基氨基甲酸酯）手性固定相上的分子对映识别

在 Chiralpak IB-U 色谱柱上分析了两种手性三苯乙烯衍生物，该色谱柱填充了基于三（3,5-二甲基苯基氨基甲酸酯）的亚 2 μm 直径颗粒。在正常相条件下，获得亚分钟基线对映分离。评估了所研究化合物的结构元素和色谱行为的差异，以确定驱动手性鉴别过程的相互作用。从实验色谱数据的评估中发现，氢键的形成对于对映异构体的分离是必不可少的。

更新日期：2021-11-19

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