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Physiologically-Regulated Adhesion of Hydrogels for Wound Dressing
Advanced Materials Interfaces ( IF 4.3 ) Pub Date : 2021-09-27 , DOI: 10.1002/admi.202101131 Mengda Xu 1, 2 , Yan Miao 1 , Jiahui Yu 1, 2 , Lidong Zhang 1
Advanced Materials Interfaces ( IF 4.3 ) Pub Date : 2021-09-27 , DOI: 10.1002/admi.202101131 Mengda Xu 1, 2 , Yan Miao 1 , Jiahui Yu 1, 2 , Lidong Zhang 1
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Adhesion allows the close contact of wound dressing materials with skin surface. However, the dressing replacement inevitably causes the secondary damage to unhealed wound, so a wound dressing material having physiologically-regulated adhesion is of high significance. Herein, a hydrogel is reported by covalently introducing cationic moieties into an elastic network. The cationic moieties are capable of electron-withdrawing that promotes a strong electrostatic interaction with polar groups of protein (high electron cloud density) from the wound skin tissue, enabling the adhesion of hydrogel on the skin surface. With the tissue metabolism, the nucleophilic skin surface forms a lipid layer that gradually destroys the electrostatic interaction and weakens the interfacial affinity. The adhesion energy can be reduced from 60 to <10 J m−2 in 7 days, so that the dressing material can be removed easily. The cationic moieties also endow the hydrogel a high water swelling ratio (reaching 25 200%) and an efficient antibacterial property. The in vivo tests demonstrate that the wound on a mouse back reaches physiological 100% healing after the hydrogel dressing treatment for 12 days. All results show that the introduction of cationic moieties makes the hydrogel more promising as a wound dressing.
中文翻译：
用于伤口敷料的水凝胶的生理调节粘附
粘附允许伤口敷料材料与皮肤表面紧密接触。然而，更换敷料不可避免地会对未愈合创面造成二次损伤，因此具有生理调节粘附性的创面敷料材料具有重要意义。在本文中，通过将阳离子部分共价引入弹性网络来报道水凝胶。阳离子部分能够吸电子，促进与来自伤口皮肤组织的蛋白质极性基团（高电子云密度）的强静电相互作用，使水凝胶粘附在皮肤表面。随着组织代谢，亲核皮肤表面形成脂质层，逐渐破坏静电相互作用，减弱界面亲和力。粘附能可以从 60 降低到 <10 J m-2 7 天，以便可以轻松去除敷料。阳离子部分还赋予水凝胶高水溶胀率（达到 25 200%）和有效的抗菌性能。体内试验表明，在水凝胶敷料处理 12 天后，小鼠背部的伤口达到生理 100% 愈合。所有结果表明，阳离子部分的引入使水凝胶更有希望作为伤口敷料。
更新日期：2021-10-22
中文翻译：
用于伤口敷料的水凝胶的生理调节粘附
粘附允许伤口敷料材料与皮肤表面紧密接触。然而，更换敷料不可避免地会对未愈合创面造成二次损伤，因此具有生理调节粘附性的创面敷料材料具有重要意义。在本文中，通过将阳离子部分共价引入弹性网络来报道水凝胶。阳离子部分能够吸电子，促进与来自伤口皮肤组织的蛋白质极性基团（高电子云密度）的强静电相互作用，使水凝胶粘附在皮肤表面。随着组织代谢，亲核皮肤表面形成脂质层，逐渐破坏静电相互作用，减弱界面亲和力。粘附能可以从 60 降低到 <10 J m-2 7 天，以便可以轻松去除敷料。阳离子部分还赋予水凝胶高水溶胀率（达到 25 200%）和有效的抗菌性能。体内试验表明，在水凝胶敷料处理 12 天后，小鼠背部的伤口达到生理 100% 愈合。所有结果表明，阳离子部分的引入使水凝胶更有希望作为伤口敷料。
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