Chiral cyclic 3-hydroxy ketones are widely used as building blocks in the synthesis of natural products and bioactive compounds. Through screening the carbonyl reductases, the chiral cyclic 3-hydroxy hexane-1-one products bearing an all-carbon chiral quaternary center could be obtained with high enantioselectivities (up to 99% ee ) and diastereoselectivities (up to 99:1 dr).

中文翻译：

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通过 1,3-环己烷二酮的酶促去对称还原合成 2,2-二取代的 3-羟基环己烷-1-酮的单一立体异构体

手性环状 3-羟基酮被广泛用作合成天然产物和生物活性化合物的构建单元。通过羰基还原酶的筛选，可以得到具有高对映选择性（高达 99% ee ）和非对映选择性（高达 99:1 dr）的具有全碳手性季铵中心的手性环状 3-羟基己烷-1-one 产物。