“Internal and External Combined” Nonradiative Decay-Based Nanoagents for Photoacoustic Image-Guided Highly Efficient Photothermal Therapy,ACS Applied Materials & Interfaces

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“Internal and External Combined” Nonradiative Decay-Based Nanoagents for Photoacoustic Image-Guided Highly Efficient Photothermal Therapy
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2021-09-24 , DOI: 10.1021/acsami.1c14020
Hua Gu ₁ , Weijian Liu ₁ , Shijie Zhen ₂ , Saran Long _{1,

3} , Wen Sun _{1,

3} , Jianfang Cao ₄ , Xueze Zhao ₁ , Jianjun Du _{1,

3} , Jiangli Fan _{1,

3} , Xiaojun Peng ₁

Affiliation

Rational manipulation of nonradiative decay channels is of crucial significance to improve photothermal conversion efficiency (PCE) and design photothermal agents. We first used the “internal and external combined” nonradiative decay strategy to enhance PCE. Specifically, organic IR-Y6 NPs with strong NIR absorption and high molar extinction coefficient were prepared and characterized. By means of TD-DFT calculations and fs-TA spectroscopy, the dual nonradiative decay channels composed of the free rotor (external strategy) and ultrafast dark excited states (DESs) between S₀ and S₁ states (internal strategy) were proved, which significantly enhanced PCE, up to 66%. IR-Y6 NPs were applied to a mice tumor model for photoacoustic image-guided photothermal therapy, showing complete tumor ablation ability and good biocompatibility for the normal organs. This work is of significance to deeply understand the nonradiation decay mechanism and rational design of high-performance PTT agents.

中文翻译：

“内外结合”非辐射衰变纳米制剂用于光声图像引导高效光热治疗

合理调控非辐射衰变通道对于提高光热转换效率（PCE）和设计光热剂具有至关重要的意义。我们首先采用“内外结合”的非辐射衰变策略来增强PCE。具体而言，制备并表征了具有强近红外吸收和高摩尔消光系数的有机IR-Y6 NP。通过TD-DFT计算和fs-TA光谱，证明了由自由转子（外部策略）和S ₀和S ₁态之间的超快暗激发态（DES）（内部策略）组成的双非辐射衰变通道， PCE显着提升，高达66%。 IR-Y6 NPs应用于小鼠肿瘤模型进行光声图像引导光热治疗，显示出完全的肿瘤消融能力和对正常器官良好的生物相容性。该工作对于深入理解非辐射衰变机理和合理设计高性能PTT药剂具有重要意义。

更新日期：2021-10-06

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