Cholesterol: Bioactivities, Structural Modification, Mechanisms of Action, and Structure-Activity Relationships,Mini-Reviews in Medicinal Chemistry

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Cholesterol: Bioactivities, Structural Modification, Mechanisms of Action, and Structure-Activity Relationships
Mini-Reviews in Medicinal Chemistry ( IF 3.3 ) Pub Date : 2021-07-31 , DOI: 10.2174/1389557521666210105123320
Kong Zhang ₁ , Tianze Li ₁ , Xijie Shan ₁ , Rongfei Lu ₁ , Shaoyong Zhang ₂ , Hui Xu ₁

Affiliation

Cholesterol, steroid alcohol, was discovered by M.E. Chevreul in 1815. Cholesterol and its derivatives showed a large variety of biological properties such as anticancer activity, anticardiac activity, anti-inflammatory activity, antimicrobial activity, anti-psychotic activity, antioxidant activity, drug-loaded activity, etc. In this mini-review, the advances of structural modification of cholesterol from 2014 to 2020 are summarized. In addition, the bioactivities, mechanisms of action and structureactivity relationships of cholesterol and its related derivatives are also discussed.

中文翻译：

胆固醇：生物活性、结构修饰、作用机制和结构-活性关系

胆固醇，类固醇醇，由 ME Chevreul 于 1815 年发现。胆固醇及其衍生物显示出多种生物学特性，如抗癌活性、抗心脏活性、抗炎活性、抗菌活性、抗精神病活性、抗氧化活性、药物-负载活性等。在这篇小综述中，总结了2014年至2020年胆固醇结构修饰的进展。此外，还讨论了胆固醇及其相关衍生物的生物活性、作用机制和构效关系。

更新日期：2021-09-24

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