Ziconotide 是 ω-MVIIA（一种锥肽）的合成版本。它是一种非阿片类镇痛药，已在许多国家获准使用。Jae Eun Kang 及其同事报告了一种使用明智选择偶联剂来高纯度合成齐考诺肽线性前体的简便偶联过程。他们还报告了简单的折叠条件，有助于形成具有正确二硫键连接和三维构象的 Ziconotide。该过程避免了多个分离和纯化步骤，并且不需要目前用于合成齐考诺肽和其他富含半胱氨酸的肽的许多添加剂。(doi: 10.1002/pep2.24223)
"点击查看英文标题和摘要"
Cover Image
Ziconotide is a synthetic version of ω-MVIIA, a conopeptide. It is a non-opioid analgesic and has been approved for use in many countries. Jae Eun Kang and co-workers report a facile coupling process for the high-purity synthesis of a linear precursor of Ziconotide using a judicious choice of coupling agents. They also report simple folding conditions that facilitate the formation of Ziconotide possessing the correct disulfide connectivity and three-dimensional conformation. The process avoids multiple isolation and purification steps, as well as eliminating the need for many additives currently used in the synthesis of Ziconotide and other cysteine-rich peptides. (doi: 10.1002/pep2.24223)
京公网安备 11010802027423号