Imidazo[1,2-b]pyridazine scaffold represents an important class of heterocyclic nucleus which provides various bioactives molecules. Among them, the successful kinase inhibitor ponatinib led to a resurgence of interest in exploring new imidazo[1,2-b]pyridazine-containing derivatives for their putative therapeutic applications in medicine. This present review intends to provide a state-of-the-art of this framework in medicinal chemistry from 1966 to nowadays, unveiling different aspects of its structure-activity relationships (SAR). This extensive literature surveil may guide medicinal chemists for the quest of novel imidazo[1,2-b]pyridazine compounds with enhanced pharmacokinetics profile and efficiency.

咪唑并[1,2- b ]哒嗪支架是一类重要的杂环核，可提供多种生物活性分子。其中，成功的激酶抑制剂普纳替尼引起了人们对探索新的含咪唑并[1,2- b ]哒嗪衍生物在医学上推定的治疗应用的兴趣。本综述旨在提供该框架从 1966 年至今在药物化学中的最新技术水平，揭示其构效关系 (SAR) 的不同方面。这种广泛的文献调查可能会指导药物化学家寻求具有增强药代动力学特征和效率的新型咪唑并[1,2- b ]哒嗪化合物。