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Kombucha ameliorates LPS-induced sepsis in a mouse model
Food & Function ( IF 5.1 ) Pub Date : 2021-08-25 , DOI: 10.1039/d1fo01839f Penghui Wang 1 , Zhihua Feng 1, 2 , Xiao Sang 1 , Wenzhi Chen 1, 2 , Xiaoni Zhang 3 , Jianbin Xiao 3 , Youqiang Chen 3 , Qi Chen 1, 2 , Minhe Yang 1 , Jingqian Su 1, 2
Food & Function ( IF 5.1 ) Pub Date : 2021-08-25 , DOI: 10.1039/d1fo01839f Penghui Wang 1 , Zhihua Feng 1, 2 , Xiao Sang 1 , Wenzhi Chen 1, 2 , Xiaoni Zhang 3 , Jianbin Xiao 3 , Youqiang Chen 3 , Qi Chen 1, 2 , Minhe Yang 1 , Jingqian Su 1, 2
Affiliation
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As a popular traditional fermented beverage, kombucha has been extensively studied for its health benefits. However, the science behind the anti-inflammatory effect of kombucha has not been well studied, and there is an urgent need to uncover the secrets of the anti-inflammatory properties of kombucha. Here, we investigate kombucha's protective effects against lipopolysaccharide (LPS)-induced sepsis and on the intestinal microecology in mice. The contents of reducing sugars, polyphenols, catechins, and organic acids in the kombucha group were identified using various methods. The results showed that the concentrations of acetic acid, gluconic acid, polyphenol, and glucuronic acid in the kombucha group were 55.70 ± 2.57 g L−1, 50.20 ± 1.92 g L−1, 2.36 ± 0.31, and 1.39 ± 0.22 g L−1, respectively. The result also demonstrated that kombucha effectively improves the survival rate from 0% to 40%, and increases the thermoregulation in LPS-treated mice, which showed decreased mobility and had lost their appetite for food. Furthermore, kombucha reduced the levels of tumor necrosis factor-α and interleukins (IL)-1β and IL-6, restored the levels of T cells and macrophages in LPS-challenged mice, alleviated the histopathological damage, and inhibited NF-κB signaling in mice with LPS-induced sepsis. We demonstrated that kombucha effectively prevents cellular immune function disorder in mice at the initial stage of sepsis and exerts an immunomodulatory effect. In addition, the effect of kombucha on the gut microbiota was investigated during sepsis. Kombucha supplementation altered the diversity of the gut microbiota and promoted the growth of butyrate-producing bacteria, which exert anti-inflammatory effects. Our results illustrate the potential of kombucha as a novel anti-inflammatory agent against the development of systemic inflammatory responses associated with sepsis.
中文翻译：
康普茶在小鼠模型中改善 LPS 诱导的败血症
作为一种流行的传统发酵饮料，康普茶因其健康益处而被广泛研究。然而，康普茶抗炎作用背后的科学尚未得到很好的研究，迫切需要揭开康普茶抗炎特性的秘密。在这里，我们研究了康普茶对脂多糖 (LPS) 诱导的败血症和小鼠肠道微生态的保护作用。使用多种方法鉴定了红茶菌组中还原糖、多酚、儿茶素和有机酸的含量。结果表明，康普茶组乙酸、葡萄糖酸、多酚和葡萄糖醛酸的浓度分别为55.70±2.57 g L -1、50.20±1.92 g L -1、2.36±0.31和1.39±0.22 g L-1， 分别。结果还表明，康普茶有效地将存活率从 0% 提高到 40%，并增加了 LPS 治疗小鼠的体温调节，这些小鼠表现出活动能力下降和对食物的食欲不振。此外，红茶菌降低了肿瘤坏死因子-α和白细胞介素 (IL)-1β 和 IL-6 的水平，恢复了 LPS 攻击小鼠中 T 细胞和巨噬细胞的水平，减轻了组织病理学损伤，并抑制了 NF-κB 信号转导。患有 LPS 诱导的败血症的小鼠。我们证明了康普茶可有效预防脓毒症初期小鼠的细胞免疫功能障碍并发挥免疫调节作用。此外，在败血症期间研究了康普茶对肠道微生物群的影响。康普茶补充剂改变了肠道微生物群的多样性，促进了产生丁酸盐的细菌的生长，从而发挥抗炎作用。我们的研究结果说明了康普茶作为一种新型抗炎剂的潜力，可以对抗与脓毒症相关的全身炎症反应的发展。
更新日期：2021-09-22
中文翻译：
康普茶在小鼠模型中改善 LPS 诱导的败血症
作为一种流行的传统发酵饮料，康普茶因其健康益处而被广泛研究。然而，康普茶抗炎作用背后的科学尚未得到很好的研究，迫切需要揭开康普茶抗炎特性的秘密。在这里，我们研究了康普茶对脂多糖 (LPS) 诱导的败血症和小鼠肠道微生态的保护作用。使用多种方法鉴定了红茶菌组中还原糖、多酚、儿茶素和有机酸的含量。结果表明，康普茶组乙酸、葡萄糖酸、多酚和葡萄糖醛酸的浓度分别为55.70±2.57 g L -1、50.20±1.92 g L -1、2.36±0.31和1.39±0.22 g L-1， 分别。结果还表明，康普茶有效地将存活率从 0% 提高到 40%，并增加了 LPS 治疗小鼠的体温调节，这些小鼠表现出活动能力下降和对食物的食欲不振。此外，红茶菌降低了肿瘤坏死因子-α和白细胞介素 (IL)-1β 和 IL-6 的水平，恢复了 LPS 攻击小鼠中 T 细胞和巨噬细胞的水平，减轻了组织病理学损伤，并抑制了 NF-κB 信号转导。患有 LPS 诱导的败血症的小鼠。我们证明了康普茶可有效预防脓毒症初期小鼠的细胞免疫功能障碍并发挥免疫调节作用。此外，在败血症期间研究了康普茶对肠道微生物群的影响。康普茶补充剂改变了肠道微生物群的多样性，促进了产生丁酸盐的细菌的生长，从而发挥抗炎作用。我们的研究结果说明了康普茶作为一种新型抗炎剂的潜力，可以对抗与脓毒症相关的全身炎症反应的发展。
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