The imbalance between oxidants and antioxidants in cancer cells would evoke oxidative stress-induced cell death, which has been demonstrated to be highly effective in treating malignant tumors. Sonodynamic therapy (SDT) adopts ultrasound (US) as the excitation source to induce the production of reactive oxygen species (ROS), which emerges as a noninvasive therapeutic strategy with deep tissue penetration depth and high clinical safety. Herein, we construct novel sonoactivated oxidative stress amplification nanoplatforms by coating MnO₂ on Au nanoparticle-anchored black phosphorus nanosheets and decorating soybean phospholipid subsequently (Au/BP@MS). The Au/BP@MS exhibit increased ROS generation efficiency under US irradiation in tumor tissues due to Au/BP nanosensitizer-induced improvement of electron-hole separation as well as MnO₂-mediated O₂ generation and GSH depletion, thus leading to notable inhibition effect on tumor growth. Moreover, tumor microenvironment-responsive biodegradability of Au/BP@MS endows them with enhanced magnetic resonance imaging guidance and clinical potential for cancer theranostics.

癌细胞中氧化剂和抗氧化剂之间的不平衡会引起氧化应激诱导的细胞死亡，这已被证明对治疗恶性肿瘤非常有效。声动力疗法（SDT）采用超声（US）作为激发源，诱导活性氧（ROS）的产生，是一种组织穿透深度深、临床安全性高的无创治疗策略。在此，我们通过在金纳米颗粒锚定的黑磷纳米片上涂覆MnO ₂并随后修饰大豆磷脂（Au/BP@MS）构建了新型声激活氧化应激放大纳米平台。由于 Au/BP 纳米敏化剂诱导的电子空穴分离的改善以及 MnO ₂介导的 O ₂生成和 GSH 消耗，Au/BP@MS 在美国照射下肿瘤组织中表现出增加的 ROS 生成效率，从而导致显着的抑制对肿瘤生长的影响。此外，Au/BP@MS 的肿瘤微环境响应性生物降解性赋予它们增强的磁共振成像指导和癌症治疗诊断的临床潜力。