日本北海道与急性发热性疾病相关的新型内罗病毒,Nature Communications

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日本北海道与急性发热性疾病相关的新型内罗病毒
Nature Communications ( IF 14.7 ) Pub Date : 2021-09-20 , DOI: 10.1038/s41467-021-25857-0
Fumihiro Kodama _{1,

2} , Hiroki Yamaguchi ₃ , Eunsil Park ₄ , Kango Tatemoto ₄ , Mariko Sashika ₅ , Ryo Nakao ₆ , Yurino Terauchi ₇ , Keita Mizuma ₈ , Yasuko Orba _{9,

10} , Hiroaki Kariwa ₇ , Katsuro Hagiwara ₁₁ , Katsunori Okazaki ₁₂ , Akiko Goto ₃ , Rika Komagome ₃ , Masahiro Miyoshi ₃ , Takuya Ito ₃ , Kimiaki Yamano ₃ , Kentaro Yoshii ₁₃ , Chiaki Funaki ₉ , Mariko Ishizuka ₉ , Asako Shigeno ₁₄ , Yukari Itakura ₉ , Lesley Bell-Sakyi ₁₅ , Shunji Edagawa ₁ , Atsushi Nagasaka ₁ , Yoshihiro Sakoda ₈ , Hirofumi Sawa _{9,

10,

16,

17} , Ken Maeda ₄ , Masayuki Saijo ₁₈ , Keita Matsuno _{10,

14,

16}

Affiliation

Sapporo City General Hospital, 060-8604, Sapporo, Japan.
Nagaoka Red Cross Hospital, 940-2085, Nagaoka, Japan.
Center of Infectious Diseases, Hokkaido Institute of Public Health, 060-0819, Sapporo, Japan.
Department of Veterinary Science, National Institute of Infectious Diseases, 162-8640, Shinjuku, Tokyo, Japan.
Laboratory of Wildlife Biology and Medicine, Faculty of Veterinary Medicine, Hokkaido University, 060-0818, Sapporo, Japan.
Laboratory of Parasitology, Faculty of Veterinary Medicine, Hokkaido University, 060-0818, Sapporo, Japan.
Laboratory of Public Health, Faculty of Veterinary Medicine, Hokkaido University, 060-0818, Sapporo, Japan.
Laboratory of Microbiology, Faculty of Veterinary Medicine, Hokkaido University, 060-0818, Sapporo, Japan.
Division of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, 001-0020, Sapporo, Japan.
International Collaboration Unit, International Institute for Zoonosis Control, Hokkaido University, 001-0020, Sapporo, Japan.
School of Veterinary Medicine, Rakuno Gakuen University, 069-8501, Ebetsu, Japan.
Laboratory of Microbiology and Immunology, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 061-0293, Ishikari-Tobetsu, Japan.
National Research Center for the Control and Prevention of Infectious Diseases, Nagasaki University, 852-8521, Nagasaki, Japan.
Division of Risk Analysis and Management, International Institute for Zoonosis Control, Hokkaido University, 001-0020, Sapporo, Japan.
Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, L3 5RF, United Kingdom.
One Health Research Center, Hokkaido University, 060-0818, Sapporo, Japan.
Global Virus Network, MD 21201, Baltimore, USA.
Department of Virology 1, National Institute of Infectious Diseases, 162-8640, Shinjuku, Tokyo, Japan.

蜱传原病毒感染（如克里米亚-刚果出血热）的负担日益加重，正成为全球公共卫生关注的问题。在本研究中，我们分别于 2019 年和 2020 年在日本北海道被蜱虫叮咬后出现急性发热性疾病的两名患者出现血小板减少症和白细胞减少症，从而鉴定出一种新的正病毒，命名为 Yezo 病毒 (YEZV)。YEZV 在系统发育上与在罗马尼亚蓖麻硬蜱中检测到的 Sulina 病毒分类。从 2014 年到 2020 年，有 7 名患者确诊 YEZV 感染，其中 4 人同时感染了疏螺旋体spp. 在野鹿和浣熊中发现了 YEZV 抗体，在北海道的蜱中也检测到了 YEZV RNA。在这项工作中，我们证明 YEZV 极有可能是发热性疾病的致病病原体，这是日本首次报道与可能由蜱传播的正内罗病毒相关的地方性感染。

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更新日期：2021-09-20

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